Analysis of chronic disease comorbidity characteristics and polypharmacy in hospitalized elders
OBJECTIVE To explore the characteristics of chronic comorbidity and polypharmacy in hospitalized elders and examine the influencing factors.METHODS The relevant clinical data were retrospectively reviewed for hospitalized chronic dis-ease elders aged ≥65 years throughout 2022.ICD-10 was employed for confirming a diagnosis of chronic disease.Gephi visualiza-tion software was utilized for examining the characteristics of chronic disease comorbidities.Multiple medications for chronic dis-eases(≥5 comorbidities)were analyzed.Logistic regression modeling was utilized for examining the influencing factors of mul-tiple medications and the database of Lexicomp® for assessing DDIs.RESULTS Among 545 elders with chronic diseases,449 cases were combined with more than two chronic diseases and the rate of chronic disease comorbidity was 82.39％.And"hyperten-sion+cerebrovascular disease"was the comorbidity pattern with the highest prevalence while endocrine,nutritional,metabolic diseases and circulatory diseases were more closely linked.Among 274 cases,more than 5 drugs were combined with a polyphar-macy rate of 50.27％and there was the highest frequency of cardiovascular system-based combination drugs.Logistic regression revealed that advanced age,coronary heart disease,diabetes mellitus,presence of chronic disease comorbidities and hypertension plus coronary heart disease were the risk factors for polypharmacy for chronic diseases.A total of 171 DDIs were detected with the highest frequency of platelet aggregation inhibitor-based DDIs and all X-rated DDIs associated with eurologic medications.CONCLUSION Chronic disease comorbidities are more prevalent and polypharmacy is common in elders.And a proper manage-ment of chronic disease comorbidities and related pharmacological services for elders should be strengthened.
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