Research advances of melittin in the field of rheumatoid arthritis
As one of common autoimmune diseases,rheumatoid arthritis(RA)seriously endangers human health.Currently its clinical treatment is mainly achieved by controlling inflammation.Due to a high frequency of serious adverse reactions of com-monly used therapeutic drugs,close monitoring is required during treatment.Thus it is imperative to develop efficacious anti-RA agents with minimal side effects.As one active component of bee toxin,melittin has a wide range of pharmacological effects.This review summarized the latest researches of melittin from the aspects of anti-inflammatory,immune regulation,analgesia,lower-ing the risk of cardiovascular disease and renal protection to provide references for a proper development of RA.
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