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肿瘤患者化疗期间泮托拉唑致痛风复发的药学实践

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质子泵抑制剂(proton pump inhibitors,PPI)在临床应用的风险逐渐受到重视,目前关注焦点多在其可致药物相互作用。临床药师通过1例痛风史肺腺癌患者化疗期间使用泮托拉唑导致痛风复发的病例,系统评价了不良反应因果关系,总结了 PPI导致痛风发作的机制,探讨了 PPI致痛风发作的危险因素,制定了肿瘤患者使用PPI的个体化监护要点,通过调整抑酸药的品种,保障了患者化疗如期进行,充分体现了临床药师的临床价值。
Pharmaceutical practice of proton pump inhibitors inducing gout recurrence in cancer patients on chemotherapy
The risks of proton pump inhibitors(PPIs)in clinical applications have attracted a growing attention of clinicians.And current focus is placed upon on their potential for drug interactions.Clinical pharmacists systematically evaluated the causal relationship of adverse reactions,summarized the mechanisms and risk factors of PPI-induced gout attacks and developed personal-ized monitoring strategies for lung adenocarcinoma patients on chemotherapy.Through adjusting the variety of acid suppressants,chemotherapeutic cycles of cancer patients might proceed as scheduled,fully reflecting the clinical value of clinical pharmacists.

proton pump inhibitorsrisk factorsgoutcancer patientspharmaceutical monitoring

宋扬、马岩、高立娜、王冬雪、李馨

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吉林大学第二医院药学部,吉林长春 130022

吉林大学第二医院放疗科,吉林长春 130022

质子泵抑制剂 危险因素 痛风 肿瘤患者 药学监护

2024

中国医院药学杂志
中国药学会

中国医院药学杂志

CSTPCD北大核心
影响因子:1.198
ISSN:1001-5213
年,卷(期):2024.44(17)