Analysis of risk factors in intracranial infectious patients with multi-drug resistant bacteria infection in neurology department
OBJECTIVE To explore the pathogenic characteristics and risk factors of multi-drug resistant bacteria(MDRO)infection in patients with intracranial infectious diseases and provide references for clinical prevention and treatment of MDRO.METHODS According to the occurrence of MDRO infections,from September 2020 to September 2022,153 patients with intracranial infectious diseases were assigned into two groups of MDRO infection(n=15)and non-MDRO infection(n=138).Single factor test and logistic regression analysis were utilized for exploring the risk factors of MDRO infections.RESULTS Single factor test indicated that age,hypoproteinemia,diabetes mellitus(DM),length of hospitalization,course of antibiotic dos-ing and invasive operation were associated with MDRO infections(P＜0.05).The results of multivariate logistic regression sug-gested that age,hypoproteinemia,DM,length of hospitalization,course of antibiotic dosing and invasive operation were indepen-dent risk factors.Fifty-eight strains of MDRO were isolated from 15 MDRO-infected patients.A great majority(53.4％)were gram-negative bacteria,including Acinetobacter baumannii(19.0％),Klebsiella pneumoniae(17.2％)and Pseudomonas aerugi-nosa(10.4％).CONCLUSION The incidence of MDRO infection with intracranial infectious diseases at Department of Neurol-ogy is 9.8％.Age,basic diseases such as DM or hypoproteinemia,length of hospitalization,course of antibiotic dosing and inva-sive operation are closely correlated with the occurrence of MDRO infection.A.baumannii,K.pneumoniae and P.aeruginosa are the major pathogens of MDRO infection in patients with intracranial infectious diseases.For high-risk patients,clinicians take some important measures to lower the incidence of MDRO infection.
neurologyintracranial infectious diseasesinfection with multi-drug resistant bacteriacharacteristics of patho-genic bacteria
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