Risk of liver function abnormalities with tigecycline:a retrospective observational study
OBJECTIVE To elucidate the characteristics and outcomes of liver function abnormalities in patients taking tige-cycline and detect the trends in liver function abnormalities before reaching the diagnostic criteria for drug-induced liver injury(DILI)METHODS For this retrospective study,the relevant clinical data of 585 adult inpatients were collected through an elec-tronic medical record system.Tigecycline was dosed for 72 h or more between January 1,2018 and January 1,2020,medical data were complete and other causes of hepatic function abnormality excluded.The liver function parameters of alanine aminotransfer-ase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and total bilirubin(TB)were analyzed.The dynamic changes in the incidence and severity grading of abnormalities of each parameter was assessed.Binary Logistic regression analysis was employed for determining independent risk factors associated with liver function abnormalities.RESULTS As com-pared with baseline values,initial and peak abnormalities values of various liver function parameters spiked markedly.Gender was identified as an independent risk factor for abnormal ALT(OR=0.507,P=0.001)or AST(OR=0.657,P=0.034).High main-tenance dose(100 mg bid)and prolonged duration(＞14 days)were independent risk factors for abnormal ALT/AST/ALP(P＜0.01 for all parameters).Furthermore,prolonged duration(＞14 days)(OR=1.699,P=0.017),surgery(OR=1.819,P=0.001)and baseline TB value beyond upper limit of normal(OR=4.079,P＜0.001)were independent risk factors for abnormal TB.CONCLUSION Clinicians should closely monitor liver function and pay greater attention to abnormal parameters of liver function after tigecycline therapy.This approach is conducive to detecting trends of liver injury and preventing further deterioration of liver function.
tigecyclineliver function abnormalitiesadverse effectrisk factor
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