Effect of dispensing robot versus manual adjustment on the quality of intravenous infusion
OBJECTIVE To explore the effect of dispensing robot versus manual dispensing on the physical stability of intra-venous drug infusion.METHODS Two commonly employed intravenous drugs were selected.And physical stability of finished infusion by dispensing robot versus manual dispensing was compared through examining particle value,pH value,osmotic pres-sure,turbidity and Tyndall phenomenon within 8h after dispensing.RESULTS For easily dissolved pantoprazole sodium for drug injection,no significant difference(P＞0.05)in particle value,pH value,osmotic pressure,turbidity and Dundar phenom-enon and finished product infusion remained stable after two dispensing methods.For insoluble cefoperazone sodium and sulbac-tam sodium for drug injection,particle size≥10 μm,≥25 μm within 4 h after robot dispensing was greater than manual dispens-ing and there were significant differences(P＜0.05).No difference(P＞0.05)existed in osmotic pressure between two methods and change in 8 h was＜10％.In terms of turbidity,there was no significant difference(P＞0.05)between two methods and the change of turbidity between 8 h after blending and 0h was＜0.5 NTU and finished product stablized after infusion.No significant difference existed in Tyndall phenomenon between two methods.There was no difference(P＞0.05)in pH value between two methods and the change of finished product was＜10％within 8h after preparation.In terms of dispensing efficiency,dispensing machine was superior to manual dispensing.CONCLUSION For easily dissolved pantoprazole sodium,physical stability of fin-ished infusion prepared by dispensing robot is no different from that prepared manually.However,for insoluble cefoperazone sodium and sulbactam sodium,particles of finished infusion prepared by manual oscillator are worse than those prepared by dis-pensing robot.Other parameters of pH value,osmotic pressure,turbidity and Tyndall phenomenon show no difference between two preparations and finished infusions remain stable.Therefore,when medical institutions use liquid dispensing machines to dis-pense relatively difficult drugs,pharmacists should evaluate the degree of dissolution of drugs and optimize dispensing steps to ensure the quality of finished infusion.
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