顺铂临床疗效和毒性相关基因多态性研究进展
Research advances on the influence of gene polymorphism on clinical efficacy of cisplatin
张蝶 1钱凤丹 1张立超1
作者信息
- 1. 上海中医药大学附属上海市中医医院药学部,上海 200071
- 折叠
摘要
顺铂是临床上治疗乳腺癌、膀胱癌等实体瘤的常用化疗药物,但是随着DNA修复、解毒、排泄等过程的发生,顺铂及其代谢产物的疗效及毒副作用个体差异较大,越来越多证据支持基因多态性对顺铂疗效及毒副反应的预测作用.该文从核苷酸切除修复途径、肝脏解毒及肾脏排泄过程的基因多态性进行综述,结合亚裔人群的突变概率,分析影响顺铂临床疗效及毒性相关的基因多态性,其中rs25487、rs11615、rs316019作为亚裔中突变率较高的单核苷酸多态性,在制定化疗方案前进行基因多态性检测,将有利于减少毒副作用,提高顺铂的临床疗效,为制定顺铂个体化给药提供借鉴意义.
Abstract
Cisplatin is a common chemotherapeutic agent for treating such solid tumors as breast and bladder cancers.Its thera-peutic responses and toxic/side effects vary greatly amongst individuals due to DNA repair,detoxification and excretion.There is growing evidence that genetic polymorphisms play a predictive role in efficacy and adverse reactions of cisplatin.This review focused upon gene polymorphisms involved in nucleotide excision repair pathways,liver detoxification and kidney elimination pro-cesses.In conjunctions with mutation probabilities in Asian populations,gene polymorphisms associated with cisplatin were ana-lyzed in terms of clinical efficacy and toxicity.Among them,rs25487,rs11615 and rs316019 are SNPs with higher mutation rates in Asians.Detecting gene polymorphisms before formulating chemotherapy regimens helps to minimize toxic/side effects and boost the clinical efficacy of cisplatin.It provided references for individualized dosing of cisplatin in clinical practices.
关键词
基因多态性/顺铂/精准医学Key words
genetic polymorphism/cisplatin/precision medicine引用本文复制引用
基金项目
上海市中医药三年行动计划项目(ZY2021-2023-0203-04)
出版年
2024
NETL
NSTL
万方数据