Research advances on the influence of gene polymorphism on clinical efficacy of cisplatin
Cisplatin is a common chemotherapeutic agent for treating such solid tumors as breast and bladder cancers.Its thera-peutic responses and toxic/side effects vary greatly amongst individuals due to DNA repair,detoxification and excretion.There is growing evidence that genetic polymorphisms play a predictive role in efficacy and adverse reactions of cisplatin.This review focused upon gene polymorphisms involved in nucleotide excision repair pathways,liver detoxification and kidney elimination pro-cesses.In conjunctions with mutation probabilities in Asian populations,gene polymorphisms associated with cisplatin were ana-lyzed in terms of clinical efficacy and toxicity.Among them,rs25487,rs11615 and rs316019 are SNPs with higher mutation rates in Asians.Detecting gene polymorphisms before formulating chemotherapy regimens helps to minimize toxic/side effects and boost the clinical efficacy of cisplatin.It provided references for individualized dosing of cisplatin in clinical practices.
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