孤独症谱系障碍治疗靶点及其药物研发进展
Advances of research and development on therapeutic targets and drugs for autism spectrum disorder
冯殿伟1
作者信息
- 1. 天津市安定医院药剂科,天津 300222
- 折叠
摘要
孤独症谱系障碍(autism spectrum disorder,ASD)的发病机制至今尚未明确.近年来,针对ASD病因或治疗靶点的研究逐渐增多,如干细胞疗法、微生物群-肠-脑轴、腺相关病毒基因治疗、兴奋-抑制(excitatory-inhibitory,E-I)失衡、内源性大麻素(endocannabinoid,eCB)系统及磷酸肌醇3-激酶(phosphoinositide3-kinase,PI3K)信号通路等.部分药物研发已取得初步进展,本文就ASD治疗靶点及药物研发情况进行综述.
Abstract
The pathogenesis of autism spectrum disorder(ASD)has remained elusive.Currently there are growing researches on the etiologies or therapeutic targets of ASD,such as stem cell therapy,microbiota-gut-brain axis,adeno-associated virus gene therapy,excitatory-inhibitory(E-I)imbalance,endocannabinoid(eCB)system and phosphoinositide3-kinase(PI3K)signaling pathway,etc.Some drugs have demonstrated some promising results.This reviews summarized the latest therapeutic targets and drug R & D for ASD.
关键词
孤独症谱系障碍/治疗靶点/药物研发Key words
autism spectrum disorder/therapeutic targets/research and development of drugs引用本文复制引用
出版年
2024
NETL
NSTL
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