首页|巴氯芬致慢性肾病患者癫痫持续状态1例

巴氯芬致慢性肾病患者癫痫持续状态1例

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1例75岁患者因慢性肾病5期长期血液透析,入院后因呃逆服用巴氯芬,未减量。第1次服药后患者出现眩晕和抽搐加重,第4次服药后出现意识障碍,临床考虑巴氯芬导致并进行血液灌流。血液灌流过程中出现癫痫样症状合并持续失神状态,动态脑电图提示癫痫,最终判断为巴氯芬导致的毒性代谢性脑病、癫痫持续状态。经持续血液透析,患者意识恢复、癫痫控制后出院。
Baclofen-induced status epilepticus in a patient with chronic kidney disease
A 75-year-old patient with stage 5 chronic kid-ney disease on long-term dialysis took normal dose of baclofen for hiccup after admission.After the first dose of baclofen,the patient experienced increased dizziness and convulsions,and after the fourth dose,the patient developed consciousness disorders.The doctor considered that the patient's condition was directly linked to baclofen intake,necessitating immedi-ate blood perfusion treatment.During the process of blood perfusion,the patient presents with epilepsy like symptoms combined with persistent absence,and the dynamic electroen-cephalogram indicates epilepsy.In this case,we believe that the condition is toxic metabolic encephalopathy and status epi-lepticus triggered by baclofen.After continuous hemodialy-sis,the patient regained consciousness and was discharged after epilepsy control.

baclofentoxic-metabolic encephalopathystatus epilepticuschronic kidney disease

郭珮、石雪萍、邹黎、徐兴星、刘滢

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重庆医药高等专科学校附属第一医院药学部,重庆 400060

重庆医药高等专科学校实训中心,重庆 401331

重庆三峡医药高等专科学校基础医学部,重庆 404120

巴氯芬 毒性代谢性脑病 癫痫持续状态 慢性肾病

2024

中国医院药学杂志
中国药学会

中国医院药学杂志

CSTPCD北大核心
影响因子:1.198
ISSN:1001-5213
年,卷(期):2024.44(18)