巴氯芬致慢性肾病患者癫痫持续状态1例
Baclofen-induced status epilepticus in a patient with chronic kidney disease
郭珮 1石雪萍 2邹黎 1徐兴星 1刘滢3
作者信息
- 1. 重庆医药高等专科学校附属第一医院药学部,重庆 400060
- 2. 重庆医药高等专科学校实训中心,重庆 401331
- 3. 重庆三峡医药高等专科学校基础医学部,重庆 404120
- 折叠
摘要
1例75岁患者因慢性肾病5期长期血液透析,入院后因呃逆服用巴氯芬,未减量.第1次服药后患者出现眩晕和抽搐加重,第4次服药后出现意识障碍,临床考虑巴氯芬导致并进行血液灌流.血液灌流过程中出现癫痫样症状合并持续失神状态,动态脑电图提示癫痫,最终判断为巴氯芬导致的毒性代谢性脑病、癫痫持续状态.经持续血液透析,患者意识恢复、癫痫控制后出院.
Abstract
A 75-year-old patient with stage 5 chronic kid-ney disease on long-term dialysis took normal dose of baclofen for hiccup after admission.After the first dose of baclofen,the patient experienced increased dizziness and convulsions,and after the fourth dose,the patient developed consciousness disorders.The doctor considered that the patient's condition was directly linked to baclofen intake,necessitating immedi-ate blood perfusion treatment.During the process of blood perfusion,the patient presents with epilepsy like symptoms combined with persistent absence,and the dynamic electroen-cephalogram indicates epilepsy.In this case,we believe that the condition is toxic metabolic encephalopathy and status epi-lepticus triggered by baclofen.After continuous hemodialy-sis,the patient regained consciousness and was discharged after epilepsy control.
关键词
巴氯芬/毒性代谢性脑病/癫痫持续状态/慢性肾病Key words
baclofen/toxic-metabolic encephalopathy/status epilepticus/chronic kidney disease引用本文复制引用
出版年
2024
NETL
NSTL
万方数据