Research status of brain derived neurotrophic factor as a novel therapeutic target for chronic complica-tions of diabetes mellitus
As a complex and global public health problem,diabetes mellitus(DM)is characterized by abnormal insulin secre-tion and various acute and chronic complications.Brain derived neurotrophic factor(BDNF),as an effective inducer of insulin secretion,may predict the occurrence and development of DM and its complications through regulating the secretion of various neu-rotransmitters,peptides and inflammatory factors.Therefore BDNF may become a novel therapeutic target for managing diabetic complications.This review summarized the structure and regulation of BDNF,the correlation between BDNF and diabetic com-plications and the pathogenesis of BDNF to provide rationales for developing novel anti-diabetic remedies.
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