脑源性神经营养因子作为糖尿病慢性并发症治疗新靶点的研究现状
Research status of brain derived neurotrophic factor as a novel therapeutic target for chronic complica-tions of diabetes mellitus
卢相月 1孙波 1傅娟 1侯红斌 1张锦 1张换换 1王亚萍 1牛璐1
作者信息
- 1. 甘肃省妇幼保健院(甘肃省中心医院)内分泌科,甘肃兰州 730000
- 折叠
摘要
糖尿病是一种复杂的、全球普遍存在的公共卫生问题,其特征是胰岛素分泌异常、容易出现各种急慢性并发症.脑源性神经营养因子(brain derived neurotrophic factor,BDNF)作为胰岛素分泌的一种有效诱导因子,通过调节各种神经递质、肽类以及炎症因子的分泌,对糖尿病及其并发症的发生发展具有一定预测和保护作用.因此,BDNF可能成为糖尿病并发症治疗的新靶点.该文主要从BDNF的结构与调节、BDNF与糖尿病并发症的相关性及发病机制等方面进行综述,以期为开发糖尿病新型治疗手段提供依据.
Abstract
As a complex and global public health problem,diabetes mellitus(DM)is characterized by abnormal insulin secre-tion and various acute and chronic complications.Brain derived neurotrophic factor(BDNF),as an effective inducer of insulin secretion,may predict the occurrence and development of DM and its complications through regulating the secretion of various neu-rotransmitters,peptides and inflammatory factors.Therefore BDNF may become a novel therapeutic target for managing diabetic complications.This review summarized the structure and regulation of BDNF,the correlation between BDNF and diabetic com-plications and the pathogenesis of BDNF to provide rationales for developing novel anti-diabetic remedies.
关键词
脑源性神经营养因子/糖尿病/糖尿病慢性并发症Key words
brain derived neurotrophic factor/diabetes mellitus/diabetic complications引用本文复制引用
基金项目
甘肃省自然科学基金项目(23JRRA1748)
出版年
2024
NETL
NSTL
万方数据