Preparation and in vitro evaluation of tetrandrine solid dispersion
OBJECTIVE To prepare tetrandrine(TET)solid dispersion(SD)to boost the solubility and in vitro dissolution of TET.METHODS After preparation by solvent method with PVPVA64,TET-SD was characterized by differential scanning calorimetry(DSC),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy(SEM),glass transition temperature(TG)and dissolution in vitro.And physicochemical properties and dissolution in vitro were examined.RESULTS The results of DSC,XRD,FTIR,SEM and TG indicated that prepared TET-SD was amorphous and intermolecular interaction existed between TET and PVPVA64.In vitro cumulative dissolution of TET-SD within 120 min was 92.95％.As compared with physical mixture of TET-SD and TET,dissolution rate spiked markedly within 120 min and water contact angle shrank.CONCLUSION The preparation method of TET-SD is both simple and reliable.And dissolution rate in vitro of TET improves.
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