目的:基于2017-2022年中国机构发表的定量药理学研究论文情况，分析中国定量药理学发展的动态变化和发展趋势。方法:系统检索PubMed、Web of Science、Scopus、中国知网、维普和万方医学6个数据库2017-2022年期间中国机构发表的定量药理学论文。应用文献计量学方法，对论文发表的数量、被引用次数、研究内容、论文作者及论文发表机构等进行可视化分析。应用社会网络图分析机构之间的合作情况。结果:共395家机构发表了中文论文483篇、英文论文900篇，其中SCI收录论文859篇。14篇SCI收录论文的被引用次数不少于30次;35家机构发表的论文数量不少于10篇;论文第一作者和通信作者的总人数为1 912人;政府监管机构和研究所发表论文的数量增长最快。论文的研究内容除群体药动学/药效学、生理药动学外，基于模型的荟萃分析、定量系统药理学等方面的论文也逐年增加，机构间合作也日趋紧密。结论:近6年来，中国定量药理相关研究的数量迅速增长，研究领域和研究内容不断拓宽和深化，研究人员队伍不断壮大，机构间的合作交流不断深入。定量药理学在模型引导的新药研发和精准用药领域中发挥着越来越重要的作用。
Biblimetric analysis and research status summary for pharmacometics in China(2017-2022)
OBJECTIVE To explore the dynamic changes and development trend of quantitative pharmacology in recent years based on the publications of Chinese institutions from 2017 to 2022.METHODS Quantitative pharmacology papers pub-lished by China institutions were systematically searched from six databases,namely PubMed,Web of Science,Scopus,China National Knowledge Infrastructure(CNKI),VIP and Wanfang Medicine.Bibliometric methods were applied for extracting num-ber of published papers,number of citations,research areas,authors and institutions.Moreover cooperation across institutions and other information were examined through social network diagram.RESULTS From 2017 to 2022,395 institutions published 483 Chinese and 900 English papers,including 859 Science Citation Index(SCI)papers,of which 14 papers were cited over 30 times in SCI and 35 institutions published over 10 papers.The total number of first and corresponding authors was 1 912.Govern-ment regulatory agencies and research institutes have witnessed the fastest growth in the number of publications.In addition to population pharmacokinetics/pharmacodynamics,physiologically based pharmacokinetics,model-based meta-analysis and quanti-tative system pharmacology spiked yearly.Inter-agency cooperation became more frequent.CONCLUSION In the past 6 years,the number of pharmacometric studys in China has jumped rapidly.Both research fields and contents are continuously broadening and deepening.Researchers are growing with deeper cooperation and exchange across institutions.Pharmacomety plays a vital role in model-informed drug development and model-informed precision dosing.
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