目的:探讨国家自然科学基金(National Natural Science Foundation of China，NSFC)对临床药理领域的资助情况，分析研究热点，为相关人员申报此基金提供参考。方法:检索NSFC官方数据库、LetPub国家自然科学基金查询系统和ZCOOL数据库，收集2016-2022年医学科学部临床药理方向的项目信息(申请代码设置:2016-2020年为H3111，2021-2022年为H3511)，包括资助年度、项目名称、项目类别、依托单位和资助金额等，采用Excel软件进行统计分析，采用CiteSpace软件进行可视化分析。结果:2016-2022年临床药理方向共资助225项，资助金额达8 934万元，资助项目数量和金额呈波动上升趋势。青年科学基金项目和面上项目是主要资助类别。项目依托单位呈现地区分布不平衡的现象，以北京、江苏、上海等地区为主，中南大学、北京大学和浙江大学表现最为突出。研究方向集中在分子机制研究，特别是肿瘤发生发展与耐药机制方向，个体化用药与不良反应也是研究重点。研究热点包括信号转导通路、基因多态性、生物标志物、PK/PD、多组学技术等。结论:NSFC对临床药理领域的研究提供了有力支持，尤其关注肿瘤等特定疾病研究。随着新技术的应用和研究深入，临床药理领域有望在未来取得更多突破和成果。
Funding overview and hotspots analysis of clinical pharmacology projects funded by National Natural Sci-ence Foundation of China from 2016 to 2022
OBJECTIVE To examine the sponsoring overviews and hotspots of clinical pharmacology projects supported by National Natural Science Foundation of China(NSFC)and provide references for fund application.METHODS For the related projects of clinical pharmacology from 2016 to 2022(application code settings:H3111 for 2016-2020,H3511 for 2021-2022),the relevant items were thoroughly retrieved from the NSFC official website,LetPub Inquiry System and ZCOOL database.Approval year,project name,sponsoring type,supporting institution and funding amount were statistically analyzed and visualized with Excel and CiteSpace software.RESULTS An aggregate of 89.34 million was allocated to 225 projects of clinical pharmacol-ogy.Both quantity and number of sponsored projects exhibited an erratic rising trend.Two major categories of support were Youth Foundation and General Program.There was an unequal regional distribution and Beijing,Jiangsu and Shanghai were three key areas.Central South University,Peking University and Zhejiang University were the most prominent.Molecular mecha-nisms,especially of tumor progression and drug resistance,became a major focus of investigation.Personalized medication and adverse reactions were important study areas as well.Signal transduction pathway,genetic polymorphism,biomarker,PK/PD and multi-omics technologies were among other study hotspots.CONCLUSION NSFC provides strong research supports for clinical pharmacology.With deepening applications and researches of novel technologies,more breakthroughs are expected in the field of clinical pharmacological researches in the future.
National Natural Science Foundation of Chinaclinical pharmacologyhotspotssponsoring overviewvisual analysis
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