Risk factors and prediction modeling for prevention failure of chemotherapy-related nausea and vomiting in breast cancer patients
OBJECTIVE To explore the influencing factors of prevention failure of chemotherapy-induced nausea and vomit-ing(CINV)in breast cancer patients and construct its prediction model.METHODS From January 2022 to December 2023,ret-rospective study was conducted for 450 breast cancer patients on chemotherapy at Fuyang People's Hospital.They were assigned into two groups of failure and control according to whether or not there was prevention failure of CINV.Multivariate logistic regression analysis was performed for examining the influencing factors of prevention failure of CINV.Receiver operating charac-teristic(ROC)curve was plotted for exploring the value of prediction model for prevention failure of CINV.RESULTS Among them,130 cases had prevention failure of CINV.Numeric rating scale(NRS)(OR=0.501,95％CI:0.350-0.716,P＜0.01),anxiety status(OR=4.169,95％CI:2.175-7.991,P=0.000),high risk of vomiting(OR=68.528,95％CI:8.807-533.203,P＜0.01),risk of intermediate vomiting(OR=3.154,95％CI:1.686-5.902,P＜0.01),low risk of vomiting(OR=5.367,95％CI:2.280-12.632,P＜0.01),oral preparation of proprietary Chinese medicine(OR=12.780,95％CI:6.321-25.836,P＜0.01)and serum albumin(OR=0.923,95％CI:0.862-0.989,P=0.023)were independent risk factors for prevention failure of CINV.Logit(P1)=0.297-0.692×NRS+1.428×anxiety status+4.227×high risk of vomiting or 1.149×risk of intermedi-ate vomiting or 1.680×low risk of vomiting+2.548×cinobufacini capsule-0.08×serum albumin,the accuracy of internal and extemal validation sets was 91.67％and 86.67％respectively.CONCLUSION The risk prediction model constructed based upon NRS/anxiety status/high risk of vomiting/risk of intermediate vomiting/low risk of vomiting/cinobufacini capsule/serum albumin has demonstrated an excellent performance.
chemotherapy-related nausea and vomitingbreast cancerpredictive modelrisk factors
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