Analysis of correlation between third-generation aromatase inhibitors and tendon disease events based upon FAERS
OBJECTIVE To explore the association of third-generation aromatase inhibitors(AIs)with tendon disease events,and provide references for clinical safety of drug use.MEHODS AIs-related tendon disease events were extracted from the FAERS database by OpenVigil 2.1 pharmacovigilance analysis tool from June 2004 to August 2,2023.The event signals of tendon disease were analyzed by reporting odds ratio(ROR)and proportional reporting ratio(PRR).RESULTS A total of 468 AIs-related tendon disease events were found.And 197,188,83 were associated with anastrozole,letrozole and ethemetane.Tendinitis events were the most common,accounting for 58.77％(275/468)of all tendon disease events.And 33.76％(158/468)of Als-related tendon disease events occurred between 40-64 years of age and 28.41％(133/468)occurred between 65-85 years of age.In terms of gender composition,females were higher than males.Signal results showed that tendinitis and tenosyno-vitis could generate suspicious signals in three AIs and the intensity was ranked as anastrozole＞letrozole＞exemestane and anas-trozole＞exemestane＞letrozole respectively.Tendon rupture did not produce a suspicious signal in three AIs while tendon pain caused a suspicious signal in anastrozole.CONCLUSION Three AIs are associated with tendinitis and tenosynovitis while the correlation with tendon rupture requires more data support.
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