摘要
目的：探讨丹参多酚酸盐与丹参酮ⅡA 磺酸钠注射液治疗冠心病心绞痛的疗效及药物经济学差异。方法：选取公安县中医医院2011年5月—2014年7月收治的冠心病心绞痛患者188例，按随机数字表法分成2组各94例。对照组患者给予丹参酮ⅡA磺酸钠注射液，观察组给予注射用丹参多酚酸盐，比较2组患者临床疗效及不良反应发生情况，记录两种药物日均成本和疗程成本的差异。结果：观察组患者总有效率为94.68％（89／94），高于对照组的77.66％（73／94），差异有统计学意义（P＜0.05）；观察组患者出现眩晕2例（2.13％），头痛2例（2.13％），血丙氨酸转氨酶升高1例（1.06％），与对照组的1例（1.06％），1例（1.06％），1例（1.06％）比较，差异无统计学意义（P＞0.05）；观察组患者日均成本为（184.30±5.50）元，疗程成本为（2576.90±26.30）元，高于对照组的（19.30±1.30）、（273.60±3.80）元，差异有统计学意义（P＜0.05）。结论：注射用丹参多酚酸盐静脉滴注方案治疗冠心病心绞痛临床疗效较丹参酮ⅡA 磺酸钠注射液突出，但丹参酮ⅡA磺酸钠注射液经济性较强，医师在临床用药时应当充分考虑患者病情发展程度及实际经济条件，选择最佳用药方案。
Abstract
OBJECTIVE:To probe into the pharmacoeconomic difference and efficacy of salvianolate and tanshinone ⅡA sulfonic acid natrium injection in treatment of angina pectoris of coronary heart disease (CHD).METHODS:188 cases with angina pectoris of CHD admitted into Hubei Gong'an County Traditional Chinese Medicine Hospital from May 2011 to Jul. 2014 were selected to be divided into two group via the random number table , with 94 cases in each.The control group were treated with intravenous tanshinoneⅡA sulfonic acid natrium injection , while the observation group received intravenous infusion therapy of salvianolate .After treatment , the clinical efficacy and incidence of adverse drug reactions in two group of patients were compared .Differences of daily cost and cost of a treatment course of the two kinds of drugs were recorded . RESULTS:The total efficiency of the observation group was 94.68%(89/94), higher than that of control group 77.66%(73/94), the difference was statistically significant (P <0.05).In observation group, there were 2 cases of megrim (2.13%), 2 cases of headache (2.13%) and 1 case with the increase of serum glutamic pyruvic transaminase (1.06%);and compared with the control group , respectively 1 case (1.06%), 1 case (1.06%) and 1 case (1.06%), the difference was not statistically significant ( P >0.05 ).The daily cost and cost of a treatment course of observation group were (184.30 ±5.50) yuan and (2 576.90 ±26.30) yuan, higher than that of control group (19.30 ±1.30) yuan and (273.60 ± 3.80) yuan, with statistically significant difference ( P <0.05).CONCLUSIONS: The clinical efficacy of intravenous infusion of salvianolate injection is more prominent than that of tanshinone II A sulfonate injection, but the economy of tanshinone IIA sulfonate sodium injection is stronger.Meanwhile, the physicians should fully consider the degree of disease progression and the actual economic conditions of patients in clinical medication , so as to choose the best treatment scheme .
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