Effects of Probiotic-Assisted Sakubactril Valsartan+Amiodarone on Short and Long Term Efficacy of Atrial Fibrillation After Radiofrequency Ablation
OBJECTIVE:To probe into the effects of probiotic-assisted sakubactril valsartan+amiodarone on short and long term efficacy of atrial fibrillation after radiofrequency ablation(RFCA)based on cardiovascular adverse events and recurrence rate.METHODS:A total of 90 patients with atrial fibrillation undergoing RFCA from Jun.2021 to Jun.2022 were extracted to be divided into the control group,observation group and probiotic group according to different treatment regimens,with 30 cases in each group.The control group was given amiodarone,while the observation group received sackubactril valsartan+amiodarone,and the probiotic group was treated with probiotic-assisted sakubactril valsartan+amiodarone.The atrial structure indicators[left atrial diameter(LAD),left atrial volume index(LAVI),left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume index(LVEDVI),mitral regentation area(MRA),left ventricular end-systolic volume index(LVESVI)],myocardial fibrosis indicators[soluble growth stimulation gene 2 protein(sST2),galactogenin-3(Gal-3)],neuroendocrine factors[angiotensin Ⅱ(Ang Ⅱ),norepinephrine(NE)],intestinal microbiota metabolites[total bile acid,trimethylamine oxide(TMAO)],adverse drug reactions,short and long term cardiovascular adverse events,recurrence rate were compared among three groups at different time points(before treatment,after treatment of 3 months,6 months and 12 months).RESULTS:After treatment of 3 months,6 months and 12 months,LAD,LAVI,MRA,LVEDVI and LVESVI in probiotic group were lower than those in observation group and control group,and LVEF was higher than those in observation group and control group,serum sST2,Gal-3,Ang Ⅱ and NE levels in probiotic group were lower than those in observation group and control group,with statistically significant differences(P＜0.05).Serum total bile acid and TMAO levels in probiotic group after treatment of 3 months,6 months and 12 months were lower than those before treatment,and the probiotic group was lower than the observation group and control group,with statistically significant differences(P＜0.05).There was no significant difference in the incidence of dizziness,nausea,hypotension,cough and abnormal liver function among three groups(P＞0.05).The long term recurrence rate of probiotic group was lower than that of observation group and control group,with statistically significant difference(P＜0.05).CONCLUSIONS:Probiotic-assisted sakubactril valsartan+amiodarone for atrial fibrillation after RFCA is beneficial to improve atrial structure and myocardial fibrosis,regulate neuroendocrine hormones and intestinal flora metabolates,and reduce long term recurrence after RFCA.
万方数据
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