Efficacy and Safety of Naoxintong Capsules Combined with Donepezil Hydrochloride in the Treatment of Multiple Infarct Dementia
OBJECTIVE:To probe into the clinical efficacy and safety of Naoxintong capsules combined with donepezil hydrochloride in the treatment of multiple infarct dementia(MID).METHODS:Totally 85 patients with MID admitted into the emergency department of Hai'an People's Hospital from Jul.2020 to Jun.2022 were extracted to be divided into the observation group(n=44)and control group(n=41)by lottery method.Both groups were given life intervention and conventional treatment measures.The control group was treated with donepezil hydrochloride orally,while the observation group received Naoxintong capsules combined with donepezil hydrochloride orally.Changes of inflammation and oxidative stress,hemorheology,cerebral hemodynamics,neural function indicators,and adverse drug reactions were observed.RESULTS:After 8 weeks of treatment,the levels of soluble intercellular adhesion molecules,interleukin 18,malondialdehyde,high cut whole blood viscosity,low cut whole blood viscosity and fibringen in observation group were significantly lower than those in control group,while the levels of superoxide dismutase,peak flow velocity of middle cerebral artery and average blood flow velocity were significantly higher than those in control group,with statistically significant differences(P＜0.05).The Montreal cognitive assessment scale and Hasegawa simple intelligence rating scale in the observation group were significantly higher than those in the control group,with statistically significant differences(P＜0.05).The incidence of adverse drug reactions in observation group and control group was respectively 9.09％(4/44)and 7.32％(3/41),with no statistical significance(P＞0.05).CONCLUSIONS:Naoxintong capsules combined with donepezil hydrochloride can reduce the inflammation and oxidation reaction in MID patients,improve the abnormal hemorheology,increase the cerebral blood perfusion volume,and promote the recovery of nerve function with higher safety.
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