Effects of Cultivated and Natural Calculus Bovis in Xizang Drugs Naoshenbao Pills Formula on Manifestations of Plateau Heart Disease,Cardiac Function,Coagulation Function and Serum Oxidative Stress Levels in Patients with High Altitude Heart Disease
OBJECTIVE:To probe into the effects of cultivated and natural calculus bovis in the formula of Xizang drugs Naoshenbao pills on manifestations of plateau heart disease,cardiac function,coagulation function and serum oxidative stress levels in patients with high altitude heart disease(HAHD).METHODS:Eighty patients with HAHD admitted into the hospital from Sept.2019 to Aug.2022 were divided into the natural group and cultivated group via the random number table method,with 40 patients in each group.Both groups were given Xizang drugs Naoshenbao pills formula on the basis of conventional treatment,with the application of natural calculus bovis in the natural group and cultivated calculus bovis in the cultivated group.Changes of clinical symptoms,heart rate,cardiac function[right ventricular ejection fraction(RVEF),right atrial systolic wave(As),systolic pressure of pulmonary artery(SPAP)],coagulation function[activated partial thromboplastin time(APTT),fibrinogen(FIB),fibrinogen degradation product(FDP),prothrombin time(PT)],oxidative stress[superoxide dismutase(SOD),lipid peroxidation(LPO),glutathione peroxidase(GSH-Px),malondialdehyde(MDA)]and safety of two groups were compared.RESULTS:The scores of fatigue,dyspnea,chest tightness,dizziness/headache,and irritability were significantly lower in both groups after treatment than before treatment,with statistically significant differences(P＜0.05).There was no significant difference in clinical symptom scores of each dimension between natural group and cultivated group after treatment(P＞0.05).After treatment,heart rate,SPAP and As were lower in both groups than before treatment,and RVEF was higher than before treatment,with statistically significant differences(P＜0.05),and there was no statistically significant difference in cardiac function indicators and heart rate between natural group and cultivated group after treatment(P＞0.05).After treatment,PT and APTT were higher in both groups than before treatment,FDP and FIB were lower in both groups than before treatment,with statistically significant differences(P＜0.05).There was no significant difference in coagulation function indicators between two groups after treatment(P＞0.05).Compared with before treatment,SOD and GSH-Px increased and LPO and MDA decreased in both groups after treatment,the differences were statistically significant(P＜0.05).After treatment,there was no statistical significance in serum oxidative stress indicator between two groups(P＞0.05).The incidence of adverse drug reactions in the natural group was 7.50％(3/40),higher than 2.50％(1/40)in the cultivated group,with no significant difference(P＞0.05).CONCLUSIONS:The application of natural and cultivated calculus bovis in the formula of Xizang drugs Naoshenbao pills has the same effect,and the combination with conventional treatment can alleviate the oxidative stress injury of patients with HAHD,improve the coagulation indicator,and promote the improvement of the patients'clinical conditions with higher safety.
万方数据
维普
