Clinical Efficacy of Liuwei Dihuang Pills and Erzhi Pills Prescription Combined with Conventional Western Medicine in the Treatment of Patients with Early Diabetic Nephropathy(Liver-Kidney Yin Deficiency Syndrome)
OBJECTIVE:To probe into the efficacy of Liuwei Dihuang pills and Erzhi pills combined with Empagliflozin tablets and Valsartan tablets in the treatment of patients with early diabetic nephropathy(liver-kidney Yin deficiency syndrome)and the effects on blood glucose indicator,kidney function,serum monocyte chemotactic protein-1(MCP-1),transforming growth factor-β1(TGF-β1)and inflammatory factors.METHODS:A total of 128 patients with DN(early liver-kidney yin deficiency syndrome)in this hospital from Sept.2020 to Feb.2023 were extracted to be divided into control group and observation group via the random number table method,with 64 cases in each group.Two groups were given health education and dietary guidance,on the basis of which the control group was given oral treatment of Empagliflozin tablets and Valsartan tablets,the observation group received Liuwei Dihuang pills and Erzhi pills prescription on the basis of the control group,with 8 weeks of total treatment.Clinical efficacy and occurrence of adverse drug reactions were evaluated.Blood glucose indicators[fasting blood glucose(FBG),glycated hemoglobin(HbA1c)],renal function[blood urea nitrogen(BUN),serum creatinine(SCr),urinary albumin excretion rate(UAER)],serum MCP-1,TGF-β1,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1 β)]levels were detected before and after treatment.RESULTS:The total effective rate of observation group was 93.75％(60/64),higher than 81.25％(52/64)of control group,with statistically significant difference(P＜0.05).After treatment,the levels of FBG,HbA1c,BUN,SCr,UAER,MCP-1,TGF-β1,TNF-αand IL-1 β in both groups decreased significantly compared with those before treatment,the levels of FBG,HbA1c,BUN,SCr,UAER,MCP-1,TGF-β1,TNF-α and IL-1 β in observation group were lower than those in control group,with statistically significant differences(P＜0.05).The total incidence of adverse drug reactions in control group and observation group was respectively 12.50％(8/64)and 14.06％(9/64),with no statistical significance(P＞0.05).CONCLUSIONS:Liuwei Dihuang pills and Erzhi pills combined with Empagliflozin tablets and Valsartan tablets can effectively improve the levels of blood glucose,renal function indicators,MCP-1,TGF-β1 and inflammatory factors in patients with early DN(liver-kidney Yin deficiency syndrome),and promote clinical efficacy with higher safety.
万方数据
维普
