Short-Term Efficacy of Xihuang Capsules Combined with XP Regimen in the Treatment of Advanced Gastric Cancer and Its Effects on Tumor Markers,Cellular Immune Function and Angiogenesis Regulatory Factors in Peripheral Blood
OBJECTIVE:To probe into the short-term efficacy of Xihuang capsules combined with capecitabine+cisplatin(XP regimen)in the treatment of advanced gastric cancer and its effects on tumor markers,cellular immune function and angiogenesis regulatory factors in peripheral blood of patients.METHODS:A total of 152 patients with advanced gastric cancer admitted into Beijing Aerospace General Hospital from Jan.2019 to Mar.2022 were extracted to be divided into the observation group and control group via the random number table method,with 76 cases in each group.The control group was treated with XP regimen,while the observation group received Xihuang capsules on the basis of control group,with 21 d as a course of treatment.The short-term efficacy was evaluated after 4 consecutive courses of treatment,and the adverse reactions of two groups were recorded during the treatment.Before and after treatment,the levels of serum tumor markers[carbohydrate antigen(CA)19-9,CA72-4,carcinoembryonic antigen(CEA)]and cellular immune function[percentage of peripheral blood CD3+,CD4+,CD8+T cells,CD4+/CD8+ratio],serum levels of angiogenesis regulators[vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),transforming growth factor-β1(TGF-β1)]were detected in both groups.Long-term survival of two groups was followed up.RESULTS:The objective remission rate and disease control rate of observation group were respectively 51.32％(39/76)and 93.42％(71/76),significantly higher than 30.26％(23/76)and 82.89％(63/76)of control group,with statistically significant differences(P＜0.05).The incidences of leukopenia,thrombocytopenia and gastrointestinal reactions in the observation group were significantly lower than those in the control group,with statistically significant differences(P＜0.05).After treatment,the levels of CA19-9,CA72-4,CEA,VEGF,bFGF amd TGF-β1 in two groups decreased significantly compared with those before treatment,and the observation group was lower than the control group,with statistically significant difference(P＜0.05).After treatment,the levels of CD3+,CD4+and CD4+/CD8+ratio in peripheral blood of the observation group increased significantly compared with those before treatment,and the observation group was higher than the control group,with statistically significant difference(P＜0.05).The median progression-free survival and median overall survival in observation group were respectively 6.1 months and 12.9 months,significantly longer than 4.7 months and 9.8 months in the control group,with statistically significant differences(P＜0.05).CONCLUSIONS:Xihuang capsules combined with XP regimen in the treatment of advanced gastric cancer can effectively inhibit the level of tumor markers,regulate the expression of angiogenesis related regulatory factors,improve the cellular immune function and short-term efficacy and long-term survival benefits,and show a certain attenuated effect.
万方数据
维普
