首页|基于数据挖掘的中药洗剂治疗混合痔术后创面愈合的用药规律分析

基于数据挖掘的中药洗剂治疗混合痔术后创面愈合的用药规律分析

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目的:对中药洗剂治疗混合痔术后创面愈合的用药规律进行分析,为临床用药提供参考。方法:检索中国知网、万方数据库和维普数据库中所有中药洗剂治疗混合痔术后创面愈合的文献,建立数据库后运用Microsoft Excel 2019软件进行用药频次统计,应用古今医案云平台V1。2。4进行性味、归经及功效分析,导入IBM SPSS Modeler 18。0软件进行关联规则分析,应用IBM SPSS 25。0软件进行聚类分析。结果:共收集处方173首、中药171味,其中使用频次居前5位的中药为苦参、黄柏、芒硝、五倍子和大黄。药性多寒、温,药味以苦、辛、甘为主,主归肝、胃、心经,功效以清热燥湿、清热解毒为主。在关联规则分析中,苦参-蒲公英、黄柏-地榆为核心药对,使用频率最高,3味中药药组多为2个核心药对的加减配伍。高频药物聚类分析得到6个新的药物组合。结论:中药洗剂治疗混合痔术后创面愈合以清热燥湿、解毒消肿为主,兼有凉血止血、泻下通便类药物,其核心药物组合对混合痔术后创面愈合的理论研究及临床施治和新药的研发具有一定的参考价值。
Medication Regularity of Traditional Chinese Medicine Lotion in the Treatment of Wound Healing After Mixed Hemorrhoids Surgery Based on Data Mining
OBJECTIVE:To analyze the medication regularity of traditional Chinese medicine lotion in the treatment of wound healing after mixed hemorrhoid surgery,so as to provide reference for clinical medication.METHODS:Literature related to traditional Chinese medicine lotion in the treatment of wound healing after mixed hemorrhoid surgery were retrieved from CNKI,Wanfang Data and VIP database,Microsoft Excel 2019 was used to conduct medication frequency statistics after establishing the database,the Ancient and Modern Medical Case Cloud Platform V1.2.4 was used to perform analysis on flavors,meridian-tropism and efficacy,the data was imported into IBM SPSS Modeler 18.0 to perform association rule analysis,and the IBM SPSS 25.0 was used for cluster analysis.RESULTS:A total of 173 prescriptions and 171 flavors of traditional Chinese medicine were collected,among which the top 5 traditional Chinese medicines ranked by application frequency were sophora flavescens,cortex phellodendri,sodium sulfate,gallnut and rhubarb.The medicinal properties were mainly cold and warm,and the flavors were mainly bitter,pungent and sweet,which mainly returned to liver,stomach and heart meridians,and the efficacy was mainly for heat-clearing and damp-drying,heat-clearing and toxicity-removing.In the association rule analysis,the sophora flavescens-dandelion and cortex phellodendri-sanguisorba officinalis were the core drug pairs with the highest frequency,the three-flavored traditional Chinese medicine groups were mostly the modified compatibility of two core drug pairs.Totally six new drug combinations were obtained by high-frequency drug cluster analysis.CONCLUSIONS:The treatment of wound healing after mixed hemorrhoids surgery with traditional Chinese medicine lotion is mainly drug for heat-clearing and damp-drying,heat-clearing and toxicity-removing,as well as blood-cooling and hemorrhage-stopping,catharsis and defecation.The core drug combinations have a certain reference value for theoretical research and clinical treatment of wound healing after mixed hemorrhoids surgery,as well as the research and development of new drugs.

After mixed hemorrhoids surgeryWound healingFumigation and sitz bathData mining

李昌盛、畅立强、李仲云、宋杰

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山西中医药大学第一临床学院,太原 030619

山西省中医院肛肠科,太原 030012

混合痔术后 创面愈合 熏洗坐浴 数据挖掘

山西省中医院备案管理中药制剂科研项目

ZJ-202220

2024

中国医院用药评价与分析
中国医药生物技术协会,中国药房杂志社

中国医院用药评价与分析

CSTPCD
影响因子:1.142
ISSN:1672-2124
年,卷(期):2024.24(1)
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