Pharmacoeconomic Evaluation of Zhichuanling Oral Liquid in the Treatment of Bronchial Asthma(Cold Syndrome and Heat Syndrome)Based on Meta-Analysis
OBJECTIVE:To evaluate the economy of Zhichuanling oral liquid in the treatment of bronchial asthma(cold syndrome and heat syndrome)from the perspective of health system.METHODS:Randomized controlled trials of Zhichuanling oral liquid in the treatment of bronchial asthma(the control group was treated with conventional Western medicine,while the observation group was treated with Zhichuanling oral liquid added to the control group)in major databases until Apr.2023 were systematically reviewed,and Meta-analysis was performed by using RevMan 5.4 software.A decision tree model was constructed based on results of Meta-analysis,and cost-effectiveness analysis was used to retrospectively evaluate the economics of Zhichuanling oral liquid combined with conventional treatment regimens in the treatment of bronchial asthma(cold syndrome and heat syndrome).RESULTS:A total of 6 literature meeting the criteria were included for Meta-analysis,and the results indicate that compared to the control group,the observation group showed superior efficacy in treating bronchial asthma(cold syndrome,heat syndrome).Basing on the results of Meta-analysis,we conducted the cost-effectiveness analysis and the results revealed that the cost parameter of observation group was 8 869.41 yuan with the effect parameter(total effective rate)was 95.88％.and the cost parameter of the control group was 8 777.01 yuan with the effect parameter was 77.25％.Then we further calculated to have an incremental cost of 92.40 yuan,an incremental effect of 18.63％,and an incremental cost-effect ratio of 495.97 yuan/％.Single factor sensitivity analysis showed that the average cost of bronchial asthma treatment had the greatest influence on the results of the study.Probability sensitivity analysis showed stable results.CONCLUSIONS:For patients with bronchial asthma(cold syndrome and heat syndrome),compared with conventional treatment,Zhichuanling oral liquid combined with conventional treatment is more economical.
万方数据
维普
