Progress on Clinical Application of Glucagon-Like Peptide-1 Receptor Agonists in Children
Glucagon-like peptide-1 receptor agonists(GLP-1RA)have been widely used in the treatment of adult type 2 diabetes,and recent studies have shown that GLP-1RA can also be used in the treatment of children with obesity and short bowel syndrome.This review focuses on the progress of GLP-1RA in clinical use in children.GLP-1RA improves metabolic abnormalities and cardiovascular disease risk in children with obesity by improving insulin sensitivity,reducing weight,lowering blood pressure,and reducing the risk of developing metabolic syndrome.In short bowel syndrome,GLP-1RA can increase intestinal absorption of nutrients and can stimulate insulin secretion,thereby promoting glucose utilization and reducing exogenous glucose use,increasing fat utilization.Although GLP-1RA are safe and well tolerated in clinical use,there are risks of hypoglycemia,nausea and vomiting,pancreatitis,and thyroid cancer,so it is necessary to closely monitor the adverse drug reactions and to further carry out more systematic and in-depth studies.
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