Efficacy and Safety Analysis on 5-Aminolevulinic Acid-Photodynamic Combined with Low-Dose Isotretinoin in the Treatment of Acne Rosacea
OBJECTIVE:To probe into the efficacy and safety of 5-aminolevulinic acid(ALA-photodynamic(PDT)combined with low-dose isotretinoin in the treatment of acne rosacea(AR).METHODS:A total of 86 patients with AR admitted into the Second Affiliated Hospital of Xinjiang Medical University from Jan.2022 to Jan.2023 were selected to be divided into combination group and control group via random number table method,with 43 cases in each group.The control group was treated with low-dose isotretinoin,the combination group was given ALA-PDT combined with low-dose isotretinoin.The clinical efficacy,the skin erythema indexes(EI),Acne Specific Quality of Life Scale(Acne-QOL)scores,skin physiological function[transdermal water loss(TEWL),water content of stratum corneum and pH],cuticle integrity indexes(serine protease activity,mucin content)and incidences of adverse drug reactions before and after treatment were compared between two groups.RESULTS:The total effective rate of the combination group was 95.35%(41/43),higher than 79.07%(34/43)in the control group,with statistically significant difference(P<0.05).After treatment,the EI was lower and the Acne-QOL score was higher in the combination group than those in the control group;the TEWL and pH of the combination group were lower than those of the control group,the water content of stratum corneum of the combination group was higher than that of the control group;the serine protease activity and mucin content of the combination group were lower than those of the control group,with statistically significant differences(P<0.05).The incidences of adverse drug reactions of the combination group and control group were respectively 9.30%(4/43)and 11.63%(5/43),the difference was not statistically significant(P>0.05).CONCLUSIONS:The combination of ALA-PDT with low-dose isotretinoin in the treatment of AR can repair skin barrier function,improve EI and promote patients'quality of life,with significant efficacy and high safety.
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