Effects of Baihe Liyan Capsules on Swallowing Function,Immunity and Analgesia in Patients with Acute Laryngopharyngitis of Lung-Stomach Excess-Heat Syndrome
OBJECTIVE:To probe into the effects of Baihe Liyan capsules on swallowing function,immunity and analgesia in patients with acute laryngopharyngitis of lung-stomach excess-heat syndrome.METHODS:A total of 260 patients with acute laryngopharyngitis admitted into the hospital from 2021 to 2022 were selected to be divided into control group and observation group via random number table method.The 130 cases(7 cases withdraw,123 cases actually enrolled)in the control group were given conventional treatment,and 130 cases(5 cases withdraw,125 cases actually enrolled)in the Baihe Liyan capsules group were given Baihe Liyan capsules based on the control group.The vascular cell adhesion molecule(VCAM-1),hypersensitivity C reaction protein(hs-CRP),secreted immunoglobulin A(SIgA),interleukin 1β(IL-1β),tumor necrosis factor α(TNF-α),CD4+ and CD8+ levels were detected before and after treatment,the disappearance time of throat irritation,cough cessation time,recovery time of temperature,disappearance time of hoarseness,disappearance time of pharyngeal mucosal congestion,disappearance time of throat foreign body sensation,disappearance time of posterior pharyngeal lymphatic follicular swelling of the two groups were recorded,the traditional Chinese medicine(TCM)syndrome scores and Functional Swallowing Disorder Screening Scale(EAT10)scores of patients were evaluated,the clinical efficacy and incidences of adverse drug reactions were compared between two groups.RESULTS:The total effective rate of Baihe Liyan capsules group was 95.20%(119/125),higher than 82.93%(102/123)of the control group,with statistically significant differences(P<0.05).The recovery time of temperature,disappearance times of throat foreign body sensation,throat irritation,cough,hoarseness,pharyngeal mucosal congestion and posterior pharyngeal lymphatic follicular swelling of the Baihe Liyan capsules group were shorter than those of the control group,with statistically significant differences(P<0.05).The scores of severe sore throat or pain to ear,dysphagia,pharyngoxerosis,thirst and excessive drinking,constipated,mucousy phlegm,cough,fever,headache and deep-colored urine of the Baihe Liyan capsules group were lower than those of the control group,the EAT10 score of the Baihe Liyan capsules group was significantly lower than that of the control group,with statistically significant differences(P<0.05).After treatment,the CD4+ and SIgA levels were higher,the CD8+ level was lowe,the VCAM-1,hs-CRP,IL-1β and TNF-α levels were lower in the Baihe Liyan capsules group than those int he control group,with statistically significant differences(P<0.05).No obvious adverse drug reactions occurred in either group during treatment.CONCLUSIONS:Baihe Liyan capsules for the treatment of patients with acute laryngopharyngitis of lung-stomach excess-heat syndrome can improve body immunity,reduce inflammatory reaction,enhance throat analgesic effect,promote patients'recovery,improve the swallowing function and clinical efficacy,with high safety.
Baihe Liyan capsulesAcute laryngopharyngitisImmunityInflammatory reactionAnalgesic effectSwallowing function
万方数据
维普
