Application Effects of Midazolam and Dezocine Combined with Remifentanil in Radiofrequency Ablation in Patients with Liver Cancer
OBJECTIVE:To compare the application effects between midazolam and dezocine combined with remifentanil in radiofrequency ablation in patients with liver cancer.METHODS:A total of 97 patients with liver cancer underwent radiofrequency ablation admitted into the hospital from Dec.2019 to Dec.2022 were selected to be divided into 48 cases in the midazolam group[given midazolam load 0.05 mg/kg+remifentanil 0.05 μg/(kg·min)]and 49 cases in the dezocine group[dezocine load 0.8 mg/kg+ remifentanil 0.05 μg/(kg·min)].The heart rate(HR),oxygen saturation(SpO2)and mean arterial pressure(MAP)were compared between two groups at the time of admission to the room(T0),the time of ablation beginning(T1),10 min after ablation beginning(T2)and the end of surgery(T3);the occurrences of body movement,respiratory depression and bradycardia during surgery were recorded;the Ramsay sedation scores at T1,T2 and T3,the visual analog scale(VAS)at the end of surgery,2 h and 4 h after surgery were compared between two groups;the incidences of post-operative adverse drug reactions of both groups were recorded.RESULTS:There were no statistically significant differences in comparisons of HR,MAP,SpO2 and Ramsay sedation scores at T1,T2 and T3 between two groups(P>0.05).The incidence of complications of the dezocine group was 4.08%(2/49),lower than 16.67%(8/48)of the midazolam group,with statistically significant difference(P<0.05).The VAS scores at 2 h and 4 h after surgery were significantly lower in the dezocine group than those in the midazolam group,with statistically significant differences(P<0.05).The total incidences of adverse drug reactions of the dezocine group and the midazolam group were respectively 6.12%(3/49)and 10.42%(5/48),the difference was not statistically significant(P>0.05).CONCLUSIONS:Both midazolam and dizocine combined with remifentanil in radiofrequency ablation of liver function can achieve significant conscious analgesia,and dizocine can further reduce the incidence of intraoperative complications and alleviate triggered hyperpathia.
万方数据
维普
