Efficacy of Two Combination Therapy Regimens in the Treatment of Carbapenem-Resistant Acinetobacter Baumannii Pneumonia and Their Effects on Inflammatory Reaction
OBJECTIVE:To probe into the efficacy of cefoperazone sulbactam respectively combined with moxifloxacin and imipenem cilastatin in the treatment of carbapenem-resistant Acinetobacter baumannii(CRAB)pneumonia and its effects on inflammatory reaction.METHODS:Data of 80 patients with CRAB pneumonia admitted into the hospital from Jan.2022 to Jun.2023 were retrospectively analyzed,40 cases from Jan.to Sept.2022 were selected via convenience sampling method to be set as group A,which was given cefoperazone sulbactam combined with moxifloxacin;40 cases from Oct.2022 to Jun.2023 were selected via convenience sampling method to be set as group B,which was given cefoperazone sulbactam combined with imipenem cilastatin.The efficacy,bacterial clearance effect,recovery time of various indicators,indicators of serum inflammation and incidences of adverse drug reactions(ADR)were compared between two groups.RESULTS:The total effective rate and the bacterial clearance rate of group B were respectively 95.00%(38/40)and 90.00%(36/40),significantly higher than 80.00%(32/40)and 72.50%(29/40)of group A,with statistically significant differences(P<0.05).The recovery time of chest CT,time of fever remission and recovery time of white blood cell count of group B were shorter than those of group A,with statistically significant differences(P<0.05).After 2 weeks of treatment,the serum tumor necrosis factor α(TNF-α),procalcitonin(PCT)and interleukin 6(IL-6)levels of both groups were lower than those before treatment,the TNF-α,PCT and IL-6 levels of group B were lower than those of group A,with statistically significant differences(P<0.05).The incidence of ADR was 12.50%(5/40)in group B and 17.50%(7/40)in group A,the difference was not statistically significant(P>0.05).CONCLUSIONS:The efficacy of cefoperazone sulbactam combined with imipenem cilastatin in the treatment of CRAB pneumonia is better than that of cefoperazone sulbactam combined with moxifloxacin,which can effectively improve patients inflammation,obviously promote bacterial clearance effect,significantly short the recovery time of temperature,white blood cell count and other indicators,with few ADR.
万方数据
维普
