Effects of Recombinant Human Brain Natriuretic Peptide Combined with Bisoprolol on Efficacy of Postoperative Percutaneous Coronary Intervention,Oxidative Stress and Myocardial Injury in Patients with Acute Myocardial Infarction
OBJECTIVE:To probe into the effects of recombinant human brain natriuretic peptide combined with bisoprolol on the efficacy of percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).METHODS:A total of 90 AMI patients underwent PCI treatment admitted into the hospital from Feb.2020 to Mar.2022 were selected to be divided into control group and observation group via random number table method,with 45 cases in each group.The control group was treated with bisoprolol,while the observation group was given recombinant human brain natriuretic peptide combined with bisoprolol.The efficacy and incidences of major adverse cardiovascular events(MACE)of two groups were observed,the cardiac function[stroke volume(SV),left ventricular ejection fraction(LVEF)and cardiac output(CO)],oxidative stress[malondialdehyde(MDA),superoxide dismutase(SOD)and myeloperoxidase(MPO)]and other laboratory indicators[lipoprotein-associated phospholipase A2(Lp-PLA2),connexin 43(Cx43)and heart fatty acid binding protein(H-FABP)]were compared between two groups before and after treatment.RESULTS:The total effective rate of the observation group was 93.33%(42/45),higher than 77.78%(35/45)of the control group,with statistically significant difference(P<0.05).At 7 days and 1 month after treatment,the SV,LVEF and CO levels of the observation group were higher than those of the control group;the MPO and MDA levels were lower and the SOD level was higher in the observation group than those in the control group;the Lp-PLA2 and H-FABP levels were lower and the Cx43 level was higher in the observation group than those in the control group,with statistically significant differences(P<0.05).The incidence of MACE was 11.36%(5/44)in the observation group and 23.26%(10/43)in the control group,the difference between two groups was not statistically significant(P>0.05).CONCLUSIONS:The combination of recombinant human brain natriuretic peptide with bisoprolol in the treatment of AMI patients can significantly improve cardiac function,relieve oxidative stress,reduce the risk of MACE by regulating Lp-PLA2,H-FABP and Cx43 levels.
BisoprololRecombinant human brain natriuretic peptideOxidative stressMyocardial injuryAdverse cardiovascular events
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