Effects of Shexiang Baoxin Pills Combined with Human Brain Natriuretic Peptide on Myocardial Protection,Arterial Blood Flow Parameters,ST2 and IL-33 in Patients with Acute ST-Segment Elevation Myocardial Infarction
OBJECTIVE:To probe into the effects of Shexiang Baoxin pills combined with human brain natriuretic peptide on myocardial protection,arterial blood flow parameters,soluble growth stimulation expression gene 2(ST-2)and interleukin 33(IL-33)in patients with acute ST-segment elevation myocardial infarction.METHODS:The research subjects of this prospective study were 105 patients with acute ST-segment elevation myocardial infarction,a total of 5 cases were dislodged,and 100 cases had finally completed the course of treatment with complete records;the research period was from Mar.2021 to Mar.2023;the 100 patients were divided into research group and control group via random number table method,with 50 cases in each group.After admission,both groups were given routinely oxygen uptake and cardiac monitoring,the intravenous access was immediately established and percutaneous coronary intervention was carried out,the control group was treated with human brain natriuretic peptide for injection,and the research group was orally administered with Shexiang Baoxin pills based on the control group,both groups were treated continuously for 14 days.The TCM symptom scores of chest pain and chest tightness,palpitations,short of breath,tiredness and weakness,face and limbs swelling,asthma were compared between research group and control group before and after treatment,and the efficacy was compared,the coronary artery recirculation rates,the cardiac marker levels,arterial blood flow parameters,changes of serum ST2,IL-33,nitric oxide(NO)and endothelin-1(ET-1)levels before and after treatment were compared between research group and control group.RESULTS:After treatment,the research group had lower TCM symptom scores of chest pain and chest tightness,palpitation,short of breath,tiredness and weakness,face and limbs swelling,and asthma,with statistically significant differences(P<0.05).The total effective rate of the research group was 96.00%(48/50),which was significantly higher than 84.00%(42/50)of the control group,with statistically significant difference(P<0.05).After treatment,the serum N-terminal B-type natriuretic peptide precursor,lactate dehydrogenase,cardiac troponin T and creatine phosphokinase levels were lower in the research group compared with the control group;the coronary recirculation rate grading of the research group was significantly better than that of the control group;the left ventricular ejection fraction,left ventricular peak filling rate,peak systolic blood flow velocity,peak diastolic blood flow velocity and coronary blood flow velocity reserve of the research group were higher than those of the control group,and the left ventricular end-diastolic dimension of the research group was lower than that of the control group;the serum ST2,IL-33 and ET-1 levels of the research group were lower than those of the control group,and the serum NO level of the observation group was higher than that of the control group,the differences were statistically significant(P<0.05).CONCLUSIONS:The efficacy of Shexiang Baoxin pills combined with human brain natriuretic peptide in the treatment of acute ST-segment elevation myocardial infarction is remarkable,which helps to protect cardiomyocytes and improve arterial blood circulation,the mechanism of its myocardial protection effect may be associated with reducing ST2 and IL-33 expression as well as relieving vascular injury.
万方数据
维普
