Efficacy of Internal and External Application of Traditional Chinese Medicine Combined with Western Medicine in the Treatment of Postmenopausal Osteoporotic Thoracolumbar Compression Fracture
OBJECTIVE:To probe into the efficacy and safety of internal and external application of traditional Chinese medicine combined with Western medicine in the treatment of postmenopausal osteoporotic vertebral compression fracture(OVCF).METHODS:A total of 140 patients with postmenopausal OVCF received percutaneous kyphoplasty admitted into the hospital from Feb.2020 to Oct.2022 were selected to be divided into control group(70 cases,orally administered with Calcium carbonate D3 tablets,Calcitriol soft capsules and Alendronate sodium tablets after surgery)and research group(70 cases,Zuogui pills and Taohong Siwu decoction Huacai decoction for orally administration combined with Haitongpi decoction for external application)via random number table method,both groups were treated for 6 months.The efficacy and safety during treatment were compared between two groups,the pain condition,Oswestry disability index(ODI),bone mineral density,serum alkaline phosphatase(ALP),blood calcium and blood phosphorus levels before and after treatment were observed.RESULTS:The total effective rate of the research group was 94.29%(66/70),higher than that 80.00%(56/70)of the control group,with statistically significant difference(P<0.05).After treatment,the visual analogue scales(VAS)scores,ODI scores,serum ALP and blood phosphorus levels of both groups were lower than those before treatment,the lumbar orthostatic bone mineral density,femoral neck bone mineral density and blood calcium levels of both groups were higher than those before treatment,with statistically significant difference(P<0.05);the VAS score,ODI score,serum ALP and blood phosphorus levels of the research group were lower than those of the control group,and lumbar orthostatic bone mineral density,femoral neck bone mineral density and blood calcium level of the research group were higher than those of the control group,with statistically significant difference(P<0.05).No abnormalities in blood routine examination,urine routine examination,stool routine examination,liver/renal function and electrocardiograms were observed in both groups during treatment.CONCLUSIONS:The internal and external application of traditional Chinese medicine combined with Western medicine in the treatment of postmenopausal OVCF is safe and effective,which can relieve patients'pain,reduce the degree of dysfunction,improve bone mineral density,regulate serum ALP,blood calcium and blood phosphorus levels.
万方数据
维普
