OBJECTIVE:To systematically review the efficacy and safety of hemocoagulase agkistrodon for injection for surgical wound hemostasis.METHODS:PubMed,the Cochrane Library,Embase,CNKI,Wanfang Data and CBM were retrieved for randomized controlled trials(RCT,the research group was treated with hemocoagulase agkistrodon for injection,the control group was given placebo or blank control)on hemocoagulase agkistrodon for injection for surgical wound hemostasis published on the Key Magazine of China Technology in Chinese database and un-limited magazines in English database from base-building to Mar.2023.Literature screening,data extracting and publication bias evaluation were performed by two researchers,and Meta-analysis was conducted by using RevMan 5.3 software.RESULTS:A total of 19 RCT were enrolled,including 1 384 patients,with 716 cases in the research group and 668 cases in the control group.Results of Meta-analysis indicated that in terms of the efficacy,the effects of reducing intraoperative blood loss(MD=-65.71,95%CI=-81.99--49.43,P<0.000 01)and shortening hemostasis time(MD=-27.25,95%CI=-36.73--17.77,P<0.000 01)of the research group were better than those of the control group,with statistically significant differences;in terms of the safety,compared with the control group,the fibrinogen after 24 hours of the research group showed a certain decreasing trend,and the prothrombin time after 24 hours of the research group showed a certain shortening trend,while the differences were not statistically significant(P>0.05).CONCLUSIONS:Available evidence indicates that the hemocoagulase agkistrodon for injection has good efficacy and safety for surgical wound hemostasis.However,due to the quantitative and qualitative limitations of currently available research data,more high-quality RCT are needed in the future to further validate these findings.
关键词
注射用尖吻蝮蛇血凝酶/手术止血/Meta分析/有效性/安全性/系统评价
Key words
Hemocoagulase agkistrodon for injection/Surgical hemostasis/Meta-analysis/Efficacy/Safety/Systematic review
维普
万方数据