Bleeding Risk Evaluation of Chinese Medicine Decoctions for Promoting Blood Circulation and Removing Blood Stasis Combined with Oral Anticoagulants
OBJECTIVE:To explore the bleeding risk of Chinese medicine decoctions for promoting blood circulation and removing blood stasis combined with oral anticoagulants.METHODS:A total of 158 patients who received oral anticoagulants and Chinese medicine decoctions for promoting blood circulation and removing blood stasis in the hospital in 2022 were extracted to be divided into the combined group(n=80)and control group(n=78)according to different treatment regimen of Chinese medicine decoctions for promoting blood circulation and removing blood stasis.The oral anticoagulants in the control group included warfarin,rivaroxaban,and dabigatran etexilate;while the Chinese medicine decoctions for promoting blood circulation and removing blood stasis used in the combined group included Radix Salviae,Chuanxiong Rhizoma,Achyranthis Bidentatae Radix,etc..Prothrombin time-international normalized ratio(PT-INR),fibrinogen(FIB),D-dimer(D-D),activated partial thromboplastin time(APTT),thrombin time(TT)and incidence of bleeding events of two groups were observed.RESULTS:There were no significant differences in PT-INR,FIB,D-D,APTT and TT between the combined group and control group(P>0.05).The incidence of bleeding events in the combined treatment group was 66.25%(53/80),higher than 42.31%(33/78)in the control group,the difference was statistically significant(P<0.05).CONCLUSIONS:Although the relevant coagulation indicators do not change significantly after the combined use of Chinese medicine decoctions for promoting blood circulation and removing blood stasis and oral anticoagulants,the incidence of bleeding events in patients increased significantly.In clinical use,it is necessary to pay attention to Chinese medicine decoctions for promoting blood circulation and removing blood stasis,including Radix Salviae,Chuanxiong Rhizoma,Achyranthis Bidentatae Radix and Carthami Flos,or the combination of Chinese medicine decoctions and oral anticoagulants could increase the risk of bleeding.This study provides some reference for the study of interaction between Chinese and Western medicines.
Chinese medicine decoctions for promoting blood circulation and removing blood stasisOral anticoagulantsBleeding riskChinese combined with Western medicines
万方数据
维普
