Effects of Supplementing Qi,Nourishing Yin and Removing Blood Stasis on Microvascular Function,Arterial Blood Flow,Microvisual Field and Serum Vaspin and SCUBE2 Levels in Diabetic Retinopathy
OBJECTIVE:To observe the effects of supplementing Qi,nourishing Yin and removing blood stasis on microvascular function,arterial blood flow,microvisual field and serum lipid specific serine protease inhibitor(Vaspin)and signal peptide-CUB-EGF-like domain-containing protein(SCUBE2)levels in diabetic retinopathy.METHODS:A total of 102 patients with diabetic retinopathy were selected for hospital treatment from Jan.2021 to Dec.2022.All patients were grouped by random number table method.Fifty patients in the control group were given conventional Western medicine treatment,while 52 patients in the observation group received supplementing Qi,nourishing Yin and removing blood stasis formula on the basis of control group.Clinical efficacy,traditional Chinese medicine syndrome scores before and after treatment were compared between two groups,and the average sensitivity of visual field,visual acuity,peak systolic blood flow velocity,ocular arterial resistance index(RI)and peak diastolic blood flow velocity were detected.The proportions of Vaspin,hypoxic-inducible factor-1(HIF-1),soluble cell adhesion molecule(sICAM-1),SCUBE2,peripheral blood endothelial cell(CEC)and circulating progenitor cell(CPC)were measured.RESULTS:The total effective rate of observation group was 98.08%(51/52),higher than 84.00%(42/50)of control group,the difference was statistically significant(P<0.05).After treatment,traditional Chinese medicine syndrome score of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).After treatment,RI in observation group was lower than that in control group,peak systolic blood flow velocity,peak diastolic blood flow velocity,average sensitivity of visual field and BCVA were higher than those in control group,with statistically significant difference(P<0.05).After treatment,the CPC level in observation group was higher than that in control group,the CEC level was lower than that in control group,and levels of Vaspin,HIF-1,sICAM-1 and SCUBE2 were lower than those in control group,with statistically significant differences(P<0.05).CONCLUSIONS:Supplementing Qi,nourishing Yin and removing blood stasis formula in the treatment of diabetic retinopathy can improve the microvascular function,arterial blood flow,microvisual field and visual acuity of patients with diabetic retinopathy and improve the clinical efficacy.
Supplementing Qi,nourishing Yin and removing blood stasisDiabetic retinopathyMicrovascular functionArterial blood flowMicrovisual field
万方数据
维普
