Neuroregulatory Effects of Chaihu Shugan Powder and Banxia Houpo Decoction Combined with Wuxing Acupuncture on Anxiety and Depression After Stroke and Its Effects on Immune Inflammatory Response,Cognitive Function Impairment,HPG and HPT
OBJECTIVE:To observe the neuroregulatory effects of Chaihu Shugan powder and Banxia Houpo decoction combined with Wuxing acupuncture on anxiety and depression after stroke and its effects on immune inflammatory response,cognitive function impairment,hypothalamic-pituitary-gonadal axis(HPG)and hypothalamic-pituitary-thyroid axis(HPT).METHODS:A total of 102 patients with post-stroke anxiety and depression admitted into the hospital from Mar.2021 to May 2023 were extracted to be divided into 51 cases in the Wuxing acupuncture group(2 cases were shed and 49 cases were eventually included),and 51 cases in the prescription combination group(2 cases were shed and 49 cases were eventually included)according to the random number table method.Both groups were given conventional Western medicine basic treatment,the Wuxing acupuncture group received Wuxing acupuncture treatment based on the conventional Western medicine basic treatment,and the prescription combination group was treated with Chaihu Shugan powder and Banxia Houpo decoction on the basis of the Wuxing acupuncture group.Clinical efficacy of two groups was compared.Traditional Chinese medicine syndrome score,Mini-Mental State Examination(MMSE)score,Generalized Anxiety Disorder Scale(GAD-7)score,Hamilton Depression Scale(HAMD)score and Quality of Life Enjoyment and Satisfaction Ques-tionnaire,Short Form(Q-LES-Q-SF)score of two groups before and after treatment were compared.Serum levels of nerve growth factor(NGF),interleukin-1β(IL-1β),glial fibrillary acidic protein(GFAP),interleukin-17A(IL-17a),thyroid stimulating hormone(TSH),5-hydroxytryptamine(5-HT)and estradiol 2(E2)were measured before and after treatment.RESULTS:The total effective rate of the prescription combination group was 97.96%(48/49),higher than 81.63%(40/49)of the Wuxing acupuncture group,the difference was statistically significant(P<0.05).After treatment,the scores of anxiety and depression,epigastric fullness,chest and hypochondriac distension,frequent sighing in the prescription combination group were lower than those in the Wuxing acupuncture group,the scores of HAMD and GAD-7 were lower than those in Wuxing acupuncture group,and the scores of MMSE and Q-LES-Q-SF were higher than those in Wuxing acupuncture group,with statistically significant differences(P<0.05).After treatment,levels of of IL-1β,IL-17a and GFAP in prescription combination group were lower than those in Wuxing acupuncture group,and levels of NGF in prescription combination group were significantly higher than those in Wuxing acupuncture group,levels of 5-HT,E2 and TSH in prescription combination group were higher than those in Wuxing acupuncture group,with statistically significant differences(P<0.05).CONCLUSIONS:Chaihu Shugan powder and Banxia Houpo decoction combined with Wuxing acupuncture in the treatment of patients with post-stroke anxiety and depression can reduce the immune inflammatory response and neurological and cognitive function damage,regulate HPG and HPT,improve anxiety and depression,relieve the disease,improve quality of life and clinical efficacy.
Chaihu Shugan powder and Banxia Houpo decoctionWuxing acupuncturePost-stroke anxiety and depressionImmunoinflammatory responseHypothalamic-pituitary-gonadal axisHypothalamic-pituitary-thyroid axis
万方数据
维普
