Efficacy of Chaishao Weikang Decoction Combined with Quadruple Therapy on Helicobacter Pylori Positive Chronic Atrophic Gastritis of Liver Stomach Qi Stagnation Syndrome
OBJECTIVE:To observe the efficacy of Chaishao Weikang decoction combined with quadruple therapy on Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG)of liver stomach Qi stagnation syndrome and its effects on levels of gastrin 17(G-17),malondialdehyde(MDA),pepsinogen(PG)Ⅰ,PGⅡ,gastric mucosa tissue pathology and eradication of Hp.METHODS:A total of 140 patients with Hp positive CAG of liver stomach Qi stagnation syndrome admitted into Handan Traditional Chinese Medicine Hospital from Jun.2021 to May 2023 were extracted to be divided into the combined group and control group(with 70 cases in each group)via random number table method.The control group was given standard quadruple therapy,while combined group received Chaishao Weikang decoction on the basis of the control group.Serum levels of G-17,MDA,PGⅠand PGⅡ,gastric mucosal histopathological score,Hp eradication rate before and after treatment of two groups were compared,safety and clinical efficacy were observed.RESULTS:After treatment,serum levels of G-17 and PGⅠ increased significantly,while levels of MDA and PGⅡ and gastric mucosal histopathologic scores decreased significantly in two groups;and serum levels of G-17 and PGⅠ in combined group were higher than those in control group,while levels of MDA and PGⅡand gastric mucosal histopathologic scores were lower than those in control group,with statistically significant differences(P<0.05).The eradication rate and total effective rate of Hp in combined group were respectively 92.86%(65/70)and 92.86%(65/70),significantly higher than 81.43%(57/70)and 81.43%(57/70)in control group,the differences were statistically significant(P<0.05).CONCLUSIONS:The efficacy of Chaishao Weikang decoction combined with quadruple therapy on Hp positive CAG of liver stomach Qi stagnation syndrome is significant,which can improve gastric function,oxidative stress,and pathological damage to gastric mucosa tissue,and effectively increase the Hp eradication rate.
万方数据
维普
