Effects of Kidney-Tonifying,Phlegm-Eliminating and Blood-Activating Formula on Ovulation Induction and Anti-Müllerian Hormone,Sex Hormones Levels in Patients with Polycystic Ovary Syndrome
OBJECTIVE:To probe into the effects of kidney-tonifying,phlegm-eliminating and blood-activating formula on ovulation induction and anti-Müllerian hormone(AMH),sex hormones levels in patients with polycystic ovary syndrome(PCOS).METHODS:A total of 124 patients with PCOS admitted into Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from Jun.2020 to Jun.2022 were selected and prospectively randomized at 1∶1 ratio.Totally 62 cases in the control group was given clomiphene,while 62 patients in observation group was treated with clomiphene combined with kidney-tonifying,phlegm-eliminating and blood-activating formula.Efficacy,changes in traditional Chinese medicine syndrome scores and incidences of adverse drug reactions were compared between two groups,the number of follicles,ovarian volume,endometrial thickness,recovery of ovulation and pregnancy were observed,the serum estradiol(E2),testosterone(T),luteinizing hormone(LH),follicle-stimulating hormone(FSH)and AMH were detected.RESULTS:The comprehensive curative effect rate and overall efficacy of the observation group were respectively 85.48%(53/62)and 100.00%(62/62),which were significantly higher than 72.58%(45/62)and 90.32%(56/62)of the control group,with statistically significant differences(P<0.05).Compared with the control group,the traditional Chinese medicine syndrome score,follicles number and ovarian volume of the observation group decreased significantly after treatment,while the endometrial thickness of the observation group increased significantly,with statistically significant differences(P<0.05).Compared with the control group,the serum E2 of the observation group increased significantly after treatment,while the levels of T,LH,LH/FSH and AMH in the observation group decreased significantly,with statistically significant differences(P<0.05).The recovery rate of ovulation and pregnancy rate of 1-year follow-up were respectively 87.10%(54/62)and 43.55%(27/62)in the observation group,significantly higher than 74.19%(46/62)and 29.03%(18/62)in the control group,with statistically significant differences(P<0.05).The difference in the incidences of adverse drug reactions between two groups was not statistically significant(P>0.05),and no severe adverse drug reactions occurred.CONCLUSIONS:Kidney-tonifying,phlegm-eliminating and blood-activating formula in the treatment of PCOS can improve patients'clinical symptoms,enhance therapeutic effect,promote ovulation,regulate AMH and sex hormones levels,protect ovarian function and increase the chance of pregnancy.
Kidney-tonifying,phlegm-eliminating and blood-activating formulaPolycystic ovary syndromeOvulationSex hormone
万方数据
维普
