Clinical Efficacy and Safety of Indobufen in the Prevention of Venous Thrombosis:A Systematic Review and Meta-Analysis
OBJECTIVE:To evaluate the efficacy and safety of indobufen in the prevention of venous thrombosis.METHODS:PubMed,Embase,the Cochrane Library,ClinicalTrial.gov,CNKI,Wanfang Data and CBM were searched electronically for randomized controlled trial(RCT)of indobufen in the prevention of venous thrombosis(the interventions were indobuprofen alone or in combination with other conventional drugs,while the control measures were other positive control drugs alone or in combination with other conventional drugs)up to May 2023.Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data,and assessed the methodological quality of the included literature.Meta-analysis was performed by using RevMan 5.3 software.RESULTS:A total of 15 RCT with 2 164 patients were included.There were 1 117 patients in the indobufen group and 1 047 patients in the control group.Efficacy results showed that the there was sufficient evidence-based evidence for Meta-analysis of indobufen in thromboprophylaxis of atrial fibrillation(AF),thromboprophylaxis after major orthopedic surgery,and thromboprophylaxis of idiopathic model nephropathy,and the results were not worse than warfarin or other anticoagulants.In the prevention of thrombosis after AF combined with ischemic cardio-cerebrovascular disease,nephrotic syndrome and superficial varices of lower extremities,indobufen also had some evidence,yet it was not enough for quantitative analysis.Safety outcomes showed that the incidences of bleeding(RR=0.18,95%CI=0.09-0.38,P<0.000 01)and minor bleeding(RR = 0.17,95%CI = 0.05-0.52,P = 0.002)induced by indobufen in prevention of AF thrombosiswas were significantly lower than those in warfarin,with statistically significant differences.CONCLUSIONS:Indobufen has accumulated a certain amount of evidence-based evidence in the prevention of venous thrombosis.The clinical efficacy of indobufen in the prevention of venous thrombosis is not inferior to that of conventional therapy,and the safety of indobufen is better.
万方数据
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