Network Meta-Analysis of Traditional Chinese Medicine Injection Combined with Conventional Regimen in the Treatment of Jaundice Hepatitis
OBJCETIVE:To compare the efficacy and safety of different traditional Chinese medicine injection combined with conventional regimen in the treatment of jaundice hepatitis based on network Meta-analysis method.METHODS:CNKI,Wanfang Data,VIP,SinoMed,PubMed,the Cochrane Library,Web of Science and Embase were retrieved to collect the randomized controlled trials(RCT)of traditional Chinese medicine injection combined with conventional regimen in the treatment of jaundice hepatitis(the control group was treated with conventional regimen,without traditional Chinese medicine injection,while the observation group was given traditional Chinese medicine injection on the basis of control group)up to Sept.2022.Two researchers independently screened the literature and extracted the data.The network Meta-analysis was performed by using Stata 14 software,and the risk of literature bias was evaluated by using RStudio software.RESULTS:A total of 66 RCT were enrolled,including 6 269 patients.The intervention measures in the observation group were Tanreqing injection,Kuhuang injection,Qingkailing injection,Shuganning injection,Yanhuanglian injection,Yinzhihuang injection combined with conventional regimen,and the control group received conventional regimen.Network Meta-analysis showed that,in terms of improving the total clinical effective rate,the surface under the cumulative ranking curve(SUCRA)was Tanreqing injection(88.3%)>Qingkailing injection(77.3%)>Yanhuanglian injection(60.3%)>Shuganning injection(52.4%)>Kuhuang injection(42.1%)>Yinzhihuang injection(29.6%).In terms of improving the total clinical effective rate,the order of SUCRA was Qingkailing injection(78.3%)>Yinzhihuang injection(64.5%)>Kuhuang injection(61.0%)>Tanreqing injection(59.1%)>Shuganning injection(44.2%)>Yanhuanglian injection(41.8%).In terms of reducing direct bilirubin,the order of SUCRA was Shuganning injection(95.3%)>Kuhuang injection(61.5%)>Tanreqing injection(35.0%).CONCLUSIONS:The current evidence shows that the 6 kinds of traditional Chinese medicine injections combined with conventional regimen can significantly improve the clinical efficacy of patients with icteric hepatitis.Tanreqing injection combined with conventional regimen is the best in improving the total effective rate.In terms of reducing total bilirubin,Qingkailing injection combined with conventional regimen has a better effect.In terms of reducing direct bilirubin,Shuganning injection combined with conventional regimen has more significant effect.However,due to the limitations of different interventions and quality or quantity of included studies,this conclusion still needs to be verified by more high-level studies.
Jaundice hepatitisTraditional Chinese medicine injectionClinical efficacyNetwork Meta-analysis
万方数据
维普
