Rationality Analysis of Colistin Sulfate for Injection in 113 Patients
OBJECTIVE:To investigate the rationality of clinical application of colistin sulfate for injection in the hospital,so as to provide reference for promoting the rational application in clinic.METHODS:General information,infection site,etiological examination results,usage and dosage,drug combination and course of treatment of patients with colistin sulfate for injection in the hospital from Dec.2020 to Mar.2023 were retrospectively collected.Rationality of clinical application of colistin sulfate for injection was analyzed by referring to drug instructions,guidelines,consensus and related literature.RESULTS:A total of 113 patients treated with colistin sulfate for injection were included,of which 24 patients(21.2%)had no indication of medication.And 15 patients(13.3%)were given a loading dose.The majority of patients(101 cases,89.4%)received the minimum intravenous daily dose of 1 million U.Totally 43 patients(38.1%)were combined with aerosol inhalation and the aerosol inhalation dose was too low in one patient(0.9%).Twenty-seven patients(23.9%)received monotherapy and 4 patients(3.5%)did not meet guidelines or consensus recommendations.The treatment course was too short in 19 patients(16.8%)and too long in 8 patients(7.1%).There were some problems in the clinical application of colistin sulfate for injection in our hospital,such as incomplete medication indication,too small dosage of aerosol inhalation,no drug combination and improper treatment course.CONCLUSIONS:The application of colistin sulfate for injection in the hospital needs to be further standardized,and in-depth research on pharmacokinetics/pharmacodynamics and clinical application is urgently needed,so as to optimize the usage and dosage of colistin sulfate for injection,and improve the application rationality and treatment outcome.
Colistin sulfate for injectionCarbapenem-resistant Gram-negative bacteriaRationality analysis
万方数据
维普
