摘要
目的:系统整理经典名方寿胎丸的相关古今文献,对寿胎丸的关键信息进行考证研究,为其临床应用及制剂研发提供科学依据.方法:基于古今文献,采用现代计量学方法,对安胎经典名方寿胎丸的历史源流、组成、剂量、炮制、制法与煎服法及功效与应用进行考证分析.结果:经过文献检索,共收集古籍文献 1 条,现代临床研究 151 条.寿胎丸的药物组成为炒菟丝子、桑寄生、川续断和真阿胶,根据古今剂量折算,菟丝子 149.2 g,桑寄生、川续断和真阿胶各 74.6 g(菟丝子 ∶炒桑寄生 ∶川续断 ∶真阿胶的质量比为2∶1∶1∶1),前 3 味药制成最细粉,与水化后的阿胶制成丸剂,每丸约 0.37 g,1 次服用 20 丸,1 日 2 次,分早午服用.古籍记载寿胎丸的主治为"滑胎",现代临床主要用于复发性流产和先兆流产,其主要通过降低胚胎丢失、促进子宫内膜脱膜化、调控自噬和抑制凋亡等作用发挥妊娠保护作用.该方的主要活性成分有黄酮类、有机酸、三萜皂苷类、环烯醚萜苷类和内酯类.结论:本研究通过对安胎经典名方寿胎丸的文献考证及研究,为处方后期开发提供了参考依据.
Abstract
OBJECTIVE:To systematically collate the ancient and modern literature of the classic prescription Shoutai pills,and to research the key information of Shoutai pills,so as to provide scientific basis for its clinical application and preparation research and development.METHODS:Based on ancient and modern literature,the historical origin,composition,dosage,processing,preparation,decocting method,efficacy and application of classic prescription Shoutai pills were analyzed by modern metrology.RESULTS:Through literature search,a total of 1 ancient literature and 151 modern clinical studies were collected.Shoutai pills were made of fried Cuscuta australis,Herba Taxilli,Dipsacus asperoides and Asini Corii Colla.According to the ancient and modern dosage conversion,Cuscuta australis 149.2 g,Herba Taxilli 74.6 g,Dipsacus asperoides 74.6 g and Asini Corii Colla 74.6 g(quality of Cuscuta australis ∶Herba Taxilli ∶ Dipsacus asperoides ∶ Asini Corii Colla = 2 ∶ 1 ∶ 1 ∶ 1).The first three kinds of medicine were made into the finest powder and made into pills with hydrated Ejiao.Each pill was about 0.37 g,20 pills were taken each time,twice a day in the morning and afternoon.Ancient records showed that the main treatment of Shoutai pills was"miscarriage",and in modern clinical practice,Shoutai pills were mainly used for recurrent miscarriage and preterm miscarriage.Shoutai pills played a protective role in pregnancy mainly by reducing embryo loss,promoting endometrial demembranization,regulating autophagy and inhibiting apoptosis.The main active components of Shoutai pills were flavonoids,organic acids,triterpenoid saponins,iridoid glycosides and lactones.CONCLUSIONS:Historical evolution and textual research on classical prescription Shoutai pills for fetus protection provide reference basis for the later development of the prescription.
基金项目
国家自然科学基金青年项目(82204698)
北京市属医院科研培育计划项目(PZ2023029)
国家科技期刊平台
NSTL
万方数据