银杏叶提取物片对短暂性脑缺血发作患者血液流变学和脑氧代谢的调节机制及治疗无效的影响因素分析
Regulation Mechanism of Ginkgo Biloba Extract Tablets on Hemorheology and Cerebral Oxygen Metabolism in TIA Patients and Influence Factors of Ineffective Treatment
孟培培 1王蓓 1董魁星 1常彦青 1麻继臣 1刘立立1
作者信息
- 1. 中国人民解放军联勤保障部队第九八〇医院干部病房一科,石家庄 050000
- 折叠
摘要
目的:探讨银杏叶提取物片对短暂性脑缺血发作(TIA)患者的治疗作用与机制.方法:选取 2020 年 11 月至 2022 年 10 月该院收治的TIA患者80例,采用随机数字表法分为对照组和观察组,每组 40 例.两组患者均给予拜阿司匹林 100 mg、氯吡格雷75 mg和阿托伐他汀 20 mg联合治疗,1 日 1 次;观察组患者在此基础上联合银杏叶提取物片治疗,两组患者的疗程均为 8 周.比较两组患者治疗前后年龄、血压、临床表现、症状持续时间、糖尿病(ABCD2)评分,脑氧代谢指标和血管内皮功能指标变化,比较两组患者的临床疗效,通过Logistic回归分析探讨治疗无效的影响因素;观察两组患者不良反应及急性脑梗死(ACI)发生率.结果:治疗后,观察组患者脑静脉血氧含量、颈内静脉血氧饱和度高于对照组,ABCD2 评分、血浆炎症因子脂蛋白相关磷脂酶A2、可溶性血管细胞黏附分子-1和基质金属蛋白酶 9 水平低于对照组,差异均有统计学意义(P<0.05).观察组患者的总有效率为92.50%(37/40),高于对照组的 72.50%(29/40),差异有统计学意义(P<0.05).年龄、合并高脂血症是治疗无效的危险因素(OR分别为 1.428、1.618,P<0.05),联合银杏叶提取物是治疗无效的保护因素(OR=0.822,P<0.05).观察组与对照组患者不良反应发生率比较[10.00%(4/40)vs.5.00%(2/40)],差异无统计学意义(P>0.05);随访 6 个月,观察组患者的ACI发生率为2.50%(1/40),低于对照组的 15.00%(6/40),差异有统计学意义(P<0.05).结论:银杏叶提取物片可改善TIA患者脑氧代谢和血管内皮功能,提高临床疗效,安全性好,并可降低ACI发生率.
Abstract
OBJECTIVE:To probe into the therapeutic effect and mechanism of Ginkgo biloba extract tablets for patients with transient ischemic attack(TIA).METHODS:A total of 80 TIA patients admitted into this hospital from Nov.2020 to Oct.2022 were selected and divided into control group and observation group via random number table method,with 40 cases in each group.Both groups were given 100 mg Bayaspirin,75 mg clopidogrel and 20 mg atorvastatin for once a day;and the observation group was additionally given Ginkgo biloba extract tablets,the course of treatment was 8 weeks for both groups.The age,blood pressure,clinical features,duration of clinical symptoms,diabetes(ABCD2)scores,changes of cerebral oxygen metabolism indicators and vascular endothelial function indicators were compared between two groups before and after treatment,the clinical efficacy was compared between two groups,and the influence factors of ineffective treatment were discussed by Logistic regression analysis.The incidence of adverse drug reactions and acute cerebral infarction(ACI)were observed.RESULTS:After treatment,the cerebral venous blood oxygen content and jugular venous blood oxygen saturation of the observation group were higher than those of the control group,the ABCD2 score,plasma inflammatory factor lipoprotein-associated phospholipase A2,soluble vascular cell adhesion molecule-1 and matrix metalloproteinase 9 levels of the observation group were lower than those of the control group,with statistically significant differences(P<0.05).The total effective rate of the observation group was 92.50%(37/40),higher than that of the control group(72.50%,29/40),with statistically significant difference(P<0.05).Age and concomitant hyperlipidemia were the risk factors for ineffective treatment(OR was 1.428,1.618,respectively,P<0.05),while the combination of Gginkgo biloba extract was a protective factor for ineffective treatment(OR=0.822,P<0.05).There was no statistically significant difference in the incidences of adverse drug reactions between the observation group and the control group[10.00%(4/40)vs.5.00%(2/40),P>0.05].After 6-month follow-up,the incidence of ACI in the observation group was 2.50%(1/40),lower than 15.00%(6/40)in the control group,with statistically significant difference(P<0.05).CONCLUSIONS:Ginkgo biloba extract tablets can improve the cerebral oxygen metabolism and vascular endothelial function in TIA patients,promote clinical efficacy with higher safety,and reduce the incidence of ACI.
关键词
银杏叶提取物/短暂性脑缺血发作/脑氧代谢/血管内皮功能Key words
Ginkgo biloba extract/Transient ischemic attack/Cerebral oxygen metabolism/Vascular endothelial function引用本文复制引用
基金项目
2023年度河北省医学科学研究课题计划(20231337)
出版年
2024
国家科技期刊平台
NSTL
万方数据