磺胺嘧啶银治疗烧伤的有效性和安全性的系统评价和Meta分析
Systematic Review and Meta-Analysis on Efficacy and Safety of Silver Sulfadiazine in the Treatment of Burn
李文蕾 1郭玉金2
作者信息
- 1. 济宁医学院附属医院烧伤整形美容科,山东 济宁 272007
- 2. 济宁市第一人民医院临床药学科,山东 济宁 272002
- 折叠
摘要
目的:系统评价磺胺嘧啶银局部治疗烧伤的有效性和安全性.方法:计算机联网检索PubMed、Embase和the Cochrane Library等数据库,选取磺胺嘧啶银局部治疗烧伤的随机对照研究(干预措施为磺胺嘧啶银,对照措施为其他材料),检索时间均限定为 2010 年 1 月 1 日至 2022 年 6 月 1 日.对于纳入的随机对照研究,采用Cochrane偏倚风险评估工具评价其方法学质量,采用RevMan 5.3 软件进行Meta分析,比较磺胺嘧啶银与其他材料治疗烧伤的创面愈合时间、感染率等指标.结果:最终纳入 11 篇文献,Meta分析结果表明,与其他材料比较,磺胺嘧啶银并不能更好地缩短烧伤的创面愈合时间,差异无统计学意义(MD=-0.31,95%CI=-2.89～2.26,P=0.81);另外,磺胺嘧啶银组患者的感染率(18.09%)与其他材料组(14.81%)比较,差异无统计学意义(P>0.05).结论:基于目前的临床研究,与其他材料相比,磺胺嘧啶银在烧伤患者的创面愈合方面显示出更差的效果;在预防感染方面,磺胺嘧啶银与其他材料之间没有观察到差异.
Abstract
OBJECTIVE:To systematically review the efficacy and safety of silver sulfadiazine ointment in local treatment of burn.METHODS:PubMed,Embase,the Cochrane Library and other databases were retrieved to collect the randomized controlled study with silver sulfadiazine ointment in local treatment of burn(intervention with silver sulfadiazine and control with other materials).The retrieval time was from Jan.1st,2010 to Jun.1st,2022.For the included randomized controlled studies,Cochrane bias risk assessment tool was used to evaluate study quality,and RevMan 5.3 software was used for Meta-analysis to compare the wound healing time and infection rate of burn treated by silver sulfadiazine and other materials.RESULTS:Totally 11 studies were included.Meta-analysis results showed that compared with other materials,silver sulfadiazine could not shorten the wound healing time of burn,and the difference was not statistically significant(MD=-0.31,95%CI=-2.89-2.26,P=0.81).Meanwhile,there was no significant difference in the infection rate between silver sulfadiazine group and other materials group(18.09%vs.14.81%,P>0.05).CONCLUSIONS:Based on current clinical studies,silver sulfadiazine has shown worse effect on wound healing in burn than other materials.No differences are observed between silver sulfadiazine and other materials in the prevention of infection
关键词
磺胺嘧啶银/烧伤感染/Meta分析Key words
Silver sulfadiazine/Burn infection/Meta-analysis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据