Medication Regularity and Mechanism of Traditional Chinese Medicine in the Treatment of Bronchial Asthma Based on Data Mining and Network Pharmacology
OBJECTIVE:To probe into the prescription rule of traditional Chinese medicine in the treatment of bronchial asthma and predict the potential mechanism of core drugs,so as to provide basis and reference for the follow-up experimental research and clinical application.METHODS:Clinical literature on the treatment of bronchial asthma with traditional Chinese medicine compounds were retrieved from CNKI,Wanfang Data and VIP database.The frequency statistics and association rule analysis of traditional Chinese medicine prescriptions were carried out.Prescription rule of bronchial asthma was explored.On this basis,the core targets of high frequency drugs were screened by network pharmacology strategy.Through functional enrichment analysis of Gene Ontology and pathway enrichment analysis of Kyoto Encyclopedia of Genes and Genomes,the potential targets and pathways of drug action on diseases were studied in order to clarify the mechanism of action.RESULTS:A total of 448 studies were enrolled,including 459 prescriptions and 210 traditional Chinese medicines.Among them,drugs for resolving phlegm,relieving cough and asthma(28.70%,1 413 times/4 924 times)and tonic drugs(21.83%,1 075 times/4 924 times)were widely used.The main flavors were warm(49.31%,2 483 times/5 035 times)and pungent(29.75%,2 295 times/7 713 times),and the meridians were lung meridian(29.08%,3 608 times/12 408 times).Correlation analysis showed that there were 10 groups of high-frequency drug pairs and 10 groups of high-frequency angular drugs.Ephedra Herba was the core drug for the treatment of bronchial asthma,which had 147 intersection targets with bronchial asthma,mainly including 23 active components such as leucopelargonidin,herbacetin and leucocyanidin.Core targets were HSP90AA1,tumor proteins p53 and JUN,and the main pathways were cancer signaling pathway,lipid and atherosclerosis pathway,and diabetes complicated with advanced glycation end products(AGE)and the receptors.CONCLUSIONS:Traditional Chinese medicine in the treatment of bronchial asthma should focus on clearing lung-heat and eliminating phlegm,relieving cough and asthmatic asthma,strengthening spleen and kidney,and taking into account the application of exterior-relieving and heat-clearing drugs.The potential targets and mechanisms of Ephedra Herba are mainly involved in drug reaction,positive regulation of gene expression and negative regulation of apoptosis.
万方数据
维普
