Anesthetic Effects of Flurbiprofen Axetil Combined with Lidocaine in Patients Undergoing Gynecological Laparoscopic Surgery
OBJECTIVE:To probe into the anesthetic effects of flurbiprofen axetil combined with lidocaine in patients undergoing gynecological laparoscopic surgery.METHODS:Totally 132 patients undergoing gynecological laparoscopic surgery in Sichuan Mianyang 404 Hospital from Oct.2020 to Oct.2022 were extracted to be divided into the control group and combined group by the odd-even number method,with 66 cases in each group.The control group was intravenously injected with 10 mL 0.9%sodium chloride injection at 10 min before anesthesia induction,while the combined group was pumped with flurbiprofen axetil 1.0 mg/kg+lidocaine 1.0 mg/kg through double channels,with a continuous intraoperative infusion of lidocaine 1.0 mg/(kg·h)until the end of surgery.The intraoperative drug dosage,intraoperative bispectral indicator,analgesia quality after surgery of 4 h,6 h and 12 h,levels of serum stress response indicators[epinephrine(E),norepinephrine(NE),cortisol(Cor)]after surgery of 12 h and occurrence of adverse drug reactions within 24 h after surgery were compared between two groups.RESULTS:The total dosage of remifentanil and propofol in combined group was significantly lower than that in control group;the bispectral index in combined group was significantly lower than that in control group at 1 min before intubation,at 1 min after intubation and at 5 min after intubation;the pain scores in combined group after surgery of 4 h,6 h and 12 h were significantly lower than those in control group,while the comfort scores were significantly higher than those in control group;after surgery of 12 h,the levels of E,NE and Cor increased significantly in two groups compared with those before surgery,yet the combined group was lower than the control group,with statistically significant differences(P<0.05).Within 24 h after surgery,the total incidence of adverse drug reactions in combined group and control group was respectively 4.55%(3/66)and 7.58%(5/66),with no statistically significant difference(P>0.05).CONCLUSIONS:Flurbiprofen axetil combined with lidocaine can effectively improve the quality of anesthesia and analgesia in patients with gynecological laparoscopic surgery,reduce the perioperative stress response with higher safety.
万方数据
维普
