首页|扶正升白汤对小细胞肺癌化疗后白细胞减少症患者的影响

扶正升白汤对小细胞肺癌化疗后白细胞减少症患者的影响

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目的:探讨扶正升白汤对小细胞肺癌化疗后白细胞减少症患者白细胞计数、卡诺夫斯凯计分(KPS)的影响。方法:选取2020 年 1 月至 2021 年 3 月河北中医药大学附属沧州中西医结合医院收治的需进行化疗的小细胞肺癌患者(化疗后白细胞减少)120 例为研究对象,通过随机数字表法分为观察组(60 例,皮下注射重组人粒细胞集落刺激因子+扶正升白汤)和对照组(60 例,皮下注射重组人粒细胞集落刺激因子)。比较两组患者的临床疗效、中医证候积分、白细胞计数、中性粒细胞绝对值和KPS评分。结果:观察组患者的总有效率为 88。33%(53/60),高于对照组的 70。00%(42/60),差异有统计学意义(P<0。05)。与治疗前相比,两组患者治疗后中医证候积分降低,白细胞计数、中性粒细胞绝对值升高,KPS评分升高;且观察组患者治疗后上述指标优于对照组,差异均有统计学意义(P<0。05)。结论:扶正升白汤能显著提高小细胞肺癌化疗后白细胞减少症患者的白细胞计数,改善临床症状,提高KPS评分。
Effects of Fuzheng Shengbai Decoction on Patients with Leukopenia After Chemotherapy for Small Cell Lung Cancer
OBJECTIVE:To probe into the effects of Fuzheng Shengbai decoction on leukocytes level and Karnofsky performance score(KPS)of patients with leukopenia after chemotherapy for small cell lung cancer.METHODS:Totally 120 patients after chemotherapy for small cell lung cancer(leukopenia after chemotherapy)admitted into Cangzhou Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Hebei University of Chinese Medicine from Jan.2020 to Mar.2021 were extracted to be divided into the observation group(60 cases,subcutaneous injection of recombinant human granulocyte colony-stimulating factor+Fuzheng Shengbai decoction)and control group(60 cases,subcutaneous injection of recombinant human granulocyte colony-stimulating factor)via the random number table method.The clinical efficacy,traditional Chinese medicine syndrome score,white blood cell count,NEUT,absolute value of neutrophils and KPS score were compared between two groups.RESULTS:The total effective rate of observation group was 88.33%(53/60),higher than 70.00%(42/60)of control group,the difference was statistically significant(P<0.05).Compared with before treatment,traditional Chinese medicine syndrome score decreased,white blood cell count,NEUT and KPS score increased in two groups after treatment;the above indicators in the observation group were better than those in the control group after treatment,the differences were statistically significant(P<0.05).CONCLUSIONS:Fuzheng Shengbai decoction can obviously increase the white blood cell count in patients with leukopenia after chemotherapy for small cell lung cancer,improve the clinical symptoms and KPS score.

Fuzheng Shengbai decoctionChemotherapySmall cell lung cancerLeukopeniaFunctional status

陈晶晶、王振强、王洪亮、张庆江、赵芳、赵阳、董雪珊、周雍明

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河北中医药大学附属沧州中西医结合医院中医内科,河北 沧州 061000

石家庄平安医院肿瘤科,石家庄 050025

北京朝阳中西医结合急诊抢救医院肿瘤科五病区,北京 100023

中国中医科学院广安门医院肿瘤科,北京 100053

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扶正升白汤 化疗 小细胞肺癌 白细胞减少症 功能状态

河北省中医药管理局科研项目

2017279

2024

中国医院用药评价与分析
中国医药生物技术协会,中国药房杂志社

中国医院用药评价与分析

CSTPCD
影响因子:1.142
ISSN:1672-2124
年,卷(期):2024.24(5)
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