Effects of Fuzi Lizhong Decoction Combined with Zusanli Injection and Heat Ironing on Gastrointestinal Hormones,Inflammatory Response,Nutritional Parameters,Serum MIP-3α and Stathmin of Patients After Laparoscopic Gastric Cancer Surgery(Spleen-Stomach Defi
OBJECTIVE:To observe the effects of Fuzi Lizhong decoction combined with Zusanli injection and heat ironing on gastrointestinal hormones,inflammatory response,nutritional parameters,serum microtubule depolymerizing protein(Stathmin)and macrophage inflammatory protein-3α(MIP-3α)in patients after laparoscopic gastric cancer surgery(spleen-stomach deficiency cold syndrome).METHODS:A total of 126 patients with gastric cancer admitted into the hospital from Jan.2021 to Mar.2023 were selected and grouped by random number table method.In the control group,42 patients(2 cases dropped,40 cases eventually enrolled)were given conventional Western medicine treatment,and 42 patients(3 cases dropped,39 cases eventually enrolled)in the observation group 1 were treated with Zusanli injection combined with heat ironing therapy based on the control group,42 patients(2 cases dropped,40 cases eventually enrolled)in the observation group 2 received Fuzi Lizhong decoction on the basis of the observation group 1.The clinical efficacy of three groups was compared,and the time of first anal exhaust,first oral feeding and first defecation were recorded in three groups.Nutritional parameters(serum hemoglobin,transferrin and albumin)on the 1 d and 15 d after surgery,the inflammatory response indicators[heme oxygenase-1(HO-1),hypoxia-inducing factor-1(HIF-1α)and interleukin-6(IL-6)],gastrointestinal hormone indicators[gastrin 17(G-17),motilin(MTL)],MIP-3α and Stathmin levels of three groups were detected.RESULTS:The total effective rate of observation group 1 and observation group 2 was respectively 94.87%(37/39)and 97.50%(39/40),higher than that 75.00%(30/40)of control group,the difference was statistically significant(P<0.05).There was no significant difference in the total effective rate between observation group 2 and observation group 1(P>0.05).The time of first anal exhaust,first oral feeding and first defecation in observation group 2 was shorter than that in control group and observation group 1,and observation group 1 was shorter than control group,the differences were statistically significant(P<0.05).On the 15 d after surgery,the levels of transferrin,hemoglobin and albumin in observation group 2 were higher than those in control group and observation group 1,and observation group 1 was higher than control group;the levels of HO-1,HIF-1α and IL-6 in observation group 2 were lower than those in control group and observation group 1,and observation group 1 was lower than control group;the levels of G-17 and MTL in observation group 2 were higher than those in control group and observation group 1,and observation group 1 was higher than control group;the levels of Stathmin and MIP-3α in observation group 2 were lower than those in control group and observation group 1,and observation group 1 was lower than control group,the differences were statistically significant(P<0.05).CONCLUSIONS:Fuzi Lizhong decoction combined with Zusanli injection and hot ironing can reduce inflammatory response,regulate gastrointestinal hormone and nutritional parameter,reduce the levels of Stathmin and MIP-3α,promote disease recovery and improve clinical efficacy.
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