Clinical Observation of Compound Kushen Injection Combined with Concurrent Radiochemo-therapy in the Treatment of Nasopharyngeal Carcinoma
OBJECTIVE:To probe into the clinical therapeutic effect of compound Kushen injection combined with concurrent chemoradiotherapy in the treatment of nasopharyngeal carcinoma and its effects on radiation oral mucositis,radiation dermatitis and other adverse drug reactions of chemoradiotherapy.METHODS:Retrospective analysis was adopted,100 patients with nasopharyngeal carcinoma admitted into oncology of the hospital from 2021 to 2022 were extracted to be divided into the observation group(n=48)and control group(n=52)according to different treatment methods.The control group received synchronous radiotherapy and chemotherapy:intensity-modulated conformal radiotherapy,during which cisplatin was used for treatment.Observation group was given intravenous infusion of compound Kushen injection on the basis of control group,once a day,for 14 d,and stopped for 7 d.The treatment period for both groups was 6 weeks.The short-term efficacy evaluation,incidence of radiation oral mucositis,radiation dermatitis and other adverse drug reactions of radiotherapy and chemotherapy were compared between two groups.RESULTS:After treatment,the objective remission rate of observation group was 91.7%(44/48),higher than 88.5%(46/52)of control group,the difference was not statistically significant(P>0.05).During treatment,the incidence of radiation oral mucositis and radiation dermatitis in observation group was lower than that in control group,with statistically significant difference(P<0.05).There was no significant difference in the incidence of bone marrow suppression between two groups(P>0.05).The incidence of gastrointestinal adverse drug reactions in observation group was lower than that in control group,the difference was statistically significant(P<0.05).CONCLUSIONS:Compound Kushen injection combined with concurrent chemoradiotherapy in the treatment of nasopharyngeal carcinoma can alleviate radiation induced oral mucosal inflammation and radiation dermatitis,decrease the incidence of gastrointestinal adverse drug reactions,and improve the safety of synchronous radiotherapy and chemotherapy.
万方数据
维普
