Effects of Ziprasidone on Cognitive Function and Quality of Life in Patients with Schizophrenia
OBJECTIVE:To probe into the effects of ziprasidone on cognitive function and quality of life in patients with schizophrenia.METHODS:A total of 110 patients with schizophrenia admitted into the hospital from Jan.2022 to Jan.2023 were extracted to be divided into the control group and observation group via the random number table method,with 55 cases in each group.The control group was treated with risperidone,while the observation group received ziprasidone.Both groups were treated for 8 weeks without using other antipsychotic drugs during the treatment period.The clinical efficacy,mini mental status examination(MMSE)score,quality of life scale score(SQLS)and adverse drug reactions of two groups were compared.RESULTS:The total effective rate of observation group and control group was similar[83.64%(46/55)vs.89.09%(49/55)],with no statistically significant difference(P>0.05).After treatment,MMSE scores(orientation score,immediate memory score,delayed memory score,attention and computational power,and language and visuospatial ability score)in observation group were higher than those in control group,while SQLS scores(medium psychosocial scale,motivation/energy scale and symptom/adverse drug reaction scale)were lower than those in control group,the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in observation group was 5.45%(3/55),lower than 18.18%(10/55)in control group,the difference was statistically significant(P<0.05).CONCLUSIONS:The clinical efficacy of ziprasidone and risperidone in the treatment of schizophrenia is similar,yet ziprasidone has more significant effect on improving cognitive function and quality of life,and has higher safety.
SchizophreniaZiprasidoneRisperidoneCognitive functionQuality of life
万方数据
维普
