Meta-Analysis on Effects of Xingnaojing Injection on Inflammatory Factors in Patients with Stroke
OBJECTIVE:To probe into the effects of Xingnaojing injection on inflammatory factors in patients with stroke based on Meta-analysis,so as to so as to clarify that the common mechanism of Xingnaojing injection in the treatment of cerebral hemorrhage and cerebral infarction is to inhibit the overall inflammatory response of the body.METHODS:According to the search strategy,inclusion and exclusion criteria,CNKI,Wanfang Data,VIP,CBM,Web of Science,PubMed,Embase,the Cochrane Library and other databases were retrieved(as of Feb.20th,2023)to collect randomized controlled trial of Xingnaojing injection in the treatment of patients with stroke[the control group was given Edaravone injection or conventional brain protection therapy(excluding thrombolysis),the observation group received Xingnaojing injection on the basis of the control group].Quality evaluation method recommended by Cochrane Handbook 5.1.0 was used for literature quality evaluation.Meta-analysis and subgroup analysis were performed by RevMan 5.3 software,and Meta-regression,sensitivity analysis and publication bias evaluation were performed by Stata 12.0 software.RESULTS:Totally 12 randomized controlled trials with 1 206 patients were included.The overall level of quality of literature was low.Meta-analysis suggested that Xingnaojing injection combined with conventional treatment could reduce post C-reactive protein(SMD=-2.02,95%CI=-2.89--1.16,P<0.000 01),tumor necrosis factor α(SMD=-1.72,95%CI=-2.31--1.12,P<0.000 01)and interleukin-6(SMD=-2.14,95%CI=-2.81--1.46,P<0.000 01)after stroke,decrease the volume of brain lesions(MD=-1.55,95%CI=-1.98--1.12,P<0.000 01),the differences were statistically significant.Meta regression results suggested that type of stroke,control group with edaravone injection,and Xingnaojing injection for 20 mL once and twice a day in the observation group were not the reasons for the high heterogenicity of tumor necrosis factor α(P>0.05).CONCLUSIONS:Compared with conventional treatment,the combined application of Xingnaojing injection can reduce the levels of C-reactive protein,tumor necrosis factor α and interleukin-6 in peripheral blood after stroke,which may be the common mechanism of Xingnaojing injection in the treatment of cerebral hemorrhage and cerebral infarction.However,due to the overall low quality of the included literature,a larger and more rigorous clinical randomized controlled trial is needed to verify the findings.
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